| 陈 力,孔祥溢,方 仪,王 靖.外周血中常见血液学参数对乳腺癌预后评估价值的研究进展[J].,2019,19(23):4582-4585 |
| 外周血中常见血液学参数对乳腺癌预后评估价值的研究进展 |
| The Research Progress on the Prognostic Value of the Common Hematological Parameters in Peripheral Venous Blood in Breast Cancer |
| 投稿时间：2019-05-23 修订日期：2019-06-18 |
| DOI：10.13241/j.cnki.pmb.2019.23.042 |
| 中文关键词: 乳腺癌 预后 中性粒细胞/淋巴细胞比值（NLR） 血小板/淋巴细胞比值（PLR） 淋巴细胞/单核细胞比值（LMR） |
| 英文关键词: Breast cancer Prognosis Neutrophil to lymphocyte ratio (NLR) Platelet to lymphocyte ratio (PLR) Lymphocyte to monocyte ratio (LMR) |
| 基金项目:国家自然科学基金面上项目(81872160)；北京市自然科学基金重点项目(7191009) |
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| 中文摘要: |
| 摘要：在世界范围内，乳腺癌是最常见的女性恶性肿瘤，严重危害人民健康。最近的流行病学和临床研究发现炎性反应与乳腺肿瘤有着一定的联系。炎症构成肿瘤微环境的一部分，炎性细胞的变化影响着肿瘤的进展，包括乳腺癌细胞增殖，侵袭，免疫力降低，转移等。检验外周静脉血中的白细胞、中性粒细胞、淋巴细胞、单核细胞、血小板以及衍生出的中性粒细胞/淋巴细胞比值（NLR）、派生中性粒细胞/淋巴细胞(d-NLR)、血小板/淋巴细胞比值（PLR）、淋巴细胞/单核细胞比值（LMR）等可以反映许多恶性肿瘤细胞的炎性状态。深入研究外周血中常见的标记物与乳腺癌的治疗及预后的关系，为临床医师提供有价值的参考信息，将具有重要的临床意义和应用前景。本文就外周血中常见的标记物进行相关论述，以期为乳腺癌的治疗及预后提供一个新的方法。 |
| 英文摘要: |
| ABSTRACT: Breast carcinoma is one of the most malignant tumors, severely influencing the physical and mental health of people. The latest epidemiological and clinical studies have found that breast tumor and inflammation were determinate relationships with each other. Inflammation is an essential component of the tumor microenvironment, and the change of inflammatory cell might influence tumor progression, such as neoplastic cell proliferation, migration, invasion, collapse of antitumor immunity, metastasis and so forth. Peripheral blood tests at the time of diagnosis and treatment can reflect inflammatory conditions within the neoplasm. Evaluation of peripheral blood parameters including white blood cell, neutrophil, lymphocyte, monocyte, platelet counts, as well as neutrophil-lymphocyte ratio (NLR), derived neutrophil-lymphocyte ratio (d-NLR) (neutrophil count divided by the result of white blood cell count minus neutrophil count), platelet-lymphocyte ratio (PLR) and lymphocyte-monocyte ratio (LMR), which are indicators of systematic inflammatory response, have been widely proposed as prognostic factors for many malignancies. To intensive study the relationship between the common markers in peripheral blood and the treatment or prognosis of breast cancer will have critical clinical significance and application prospect, and can provide useful information for the clinicians. Here we review the research progress in the prognostic role of the peripheral blood in breast cancer, and to provide a new method for the treatment and prognosis of breast cancer. |
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