| 魏增永,王 波,罗建成,方侯平,王 平,乔 木,秦迎泽.全膝关节置换术在膝关节骨性关节炎治疗中的应用效果及对血清SOD、NO、TNF-α水平的影响[J].,2019,19(23):4516-4519 |
| 全膝关节置换术在膝关节骨性关节炎治疗中的应用效果及对血清SOD、NO、TNF-α水平的影响 |
| Application of Total Knee Arthroplasty for the Treatment of Knee Osteoarthritis and Its Influence on the Serum SOD, NO, TNF-α Levels |
| 投稿时间：2019-04-07 修订日期：2019-04-30 |
| DOI：10.13241/j.cnki.pmb.2019.23.027 |
| 中文关键词: 全膝关节置换术 膝关节骨性关节炎 临床疗效 超氧化物歧化酶 一氧化氮 肿瘤坏死因子-α |
| 英文关键词: Total knee replacement Osteoarthritis of the knee Clinical efficacy Superoxide dismutase Nitric oxide Tumor necrosis factor alpha |
| 基金项目:陕西省科学技术研究发展计划项目(2013K14-02-13) |
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| 中文摘要: |
| 摘要 目的：研究全膝关节置换术(TKA)治疗膝关节骨性关节炎(KOA)的临床疗效及对血清超氧化物歧化酶（SOD）、一氧化氮（NO）、肿瘤坏死因子α（TNF-α）水平的影响。方法：选取我院2014年8月到2016年1月收治的KOA患者94例，采用随机数字法将其分为对照组和观察组，每组各47例。对照组患者接受传统保守药物治疗，观察组患者接受TKA治疗，术后随访1年。比较两组患者的治疗效果，治疗前后膝关节评分(AKS)评分、视觉模拟评分法(VAS)评分及血清SOD、NO、TNF-α水平的变化。结果：治疗后，观察组的治疗效果优良率(93.61%)明显高于对照组(65.96%)(P=0.00)；治疗后随访1年，观察组的VAS评分明显低于对照组(P<0.01)，AKS中膝评分和功能评分均明显高于对照组(P<0.01)，血清SOD水平明显高于对照组(P<0.01)，血清NO和TNF-α水平均明显低于对照组(P<0.01)。结论：TKA治疗KOA患者的手术效果显著优于传统保守药物治疗，其能明显降低膝关节疼痛感，促进膝关节功能恢复，其机制可能与升高血清SOD水平，降低血清NO和TNF-α水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical efficacy of total knee arthroplasty (TKA) in the treatment of knee osteoarthritis (KOA) and its effect on the serum Superoxide dismutase (SOD), nitric oxide (NO), tumor necrosis factor (TNF-α) levels. Methods: 94 patients with KOA who admitted to our hospital from August 2014 to January 2016 were selected, they were divided into the control group and the observation group with 47 cases in each group by the random number method. Patients in the control group were treated with traditional conservative medicine, while patients in the observation group were treated with TKA and followed up for 1 year. The therapeutic effects, changes of knee joint score (AKS), visual analogue score (VAS) and serum SOD, NO and TNF-α levels before and after treatment were compared between two groups. Results: After treatment, the excellent and good rate of observation group (93.61%) was significantly higher than that in the the control group (65.96%)(P=0.00). After 1 year of follow-up, the VAS score of observation group was significantly lower than that of the control group (P<0.01), the knee score and functional score of AKS were significantly higher than those of the control group (P<0.01), the serum SOD level was significantly higher than that of the control group (P<0.01), and serum NO and TNF-α levels were significantly lower than those of the control group (P<0.01). Conclusion: The operative effect of TKA on KOA patients is significantly better than that of traditional conservative medicine, which can significantly reduce the pain sensation of knee joint and promote the recovery of knee joint function. The mechanism may be related to the increase of serum SOD level and the decrease of serum NO and TNF-α levels. |
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