| 罗燕军,胡赤军,刘 洋,鲁 明,王晓丽.复合凝乳酶对功能性消化不良儿童营养状态和摄食行为的影响[J].,2019,19(23):4479-4482 |
| 复合凝乳酶对功能性消化不良儿童营养状态和摄食行为的影响 |
| Impact of Gastropylor Complex Capsules on the Nutritional and Dietary Diversity of Children with Functional Dyspepsia |
| 投稿时间：2019-06-01 修订日期：2019-06-26 |
| DOI：10.13241/j.cnki.pmb.2019.23.018 |
| 中文关键词: 功能性消化不良 餐后不适综合征 上腹痛综合征 营养调查 复合凝乳酶 食物多样化 |
| 英文关键词: Functional dyspepsia (FD) Postprandial distress syndrome (PDS) Epigastric pain syndrome (EPS) Nutrition investigation Gastropylor Complex Capsules Dietary diversity score (DDS) |
| 基金项目:湖北省自然科学基金项目(2017CFC868) |
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| 摘要 目的：观察复合凝乳酶胶囊对不同亚型功能性消化不良儿童临床表现、营养状态和摄食行为的影响及安全性。方法：以2017年8月至2018年9月在湖北省妇幼保健院儿童消化内科就诊的功能性消化不良(Functional dyspepsia，FD)儿童为研究对象进行问卷调查，观察治疗前和复合凝乳酶治疗2 w后患儿临床症状变化及药物相关不良反应的发生情况，监测患儿身高和体重，进行膳食情况的调查。结果：共163例儿童纳入研究，发生餐后不适综合征( Postprandial distress syndrome, PDS)66例，上腹痛综合征(Epigastric pain syndrome, EPS)97例。治疗前，PDS组儿童症状总分明显高于EPS儿童(6.9±2.7 vs 3.6±1.7，t=5.90，P=0.00)。PDS组儿童WAZ、WHZ、HAZ、身高别体质量Z值(weight for height Z score，WHZ)、年龄别身高Z值(height for age Z score，HAZ)、年龄别体质量Z值(weight for age Z score，WAZ)、体质量指数(body mass index，BMI)、膳食多样化分数(Dietary diversity score, DDS)均明显低于EPS组(P均<0.05)。治疗2 w后，PDS儿童症状总分明显降低(P=0.00)，改善程度依次为：厌食>早饱>腹痛>嗳气>恶心>腹胀。EPS儿童症状总分无明显变化(P=0.11)。PDS儿童WAZ、WHZ、DDS均有明显升高(P均<0.05)。EPS儿童DDS无明显变化(t=0.22，P=0.30)。研究期间未见明显药物相关不良反应。结论：复合凝乳酶胶囊可改善PDS患儿的临床症状、营养状态和膳食多样性，且安全性高。 |
| 英文摘要: |
| ABSTRACT Objective: To evaluate the efficacy of Gastropylor Complex Capsules on the symptom, nutritional and dietary diversity of children with functional dyspepsia and its safety. Methods: Medical histories were collected in the Department of Digestive and Nutritional, Women and Children' s Hospital of Hubei Province from August 2017 to September 2018. The questionnaire investigation was performed. The changes of symptom and drug -related adverse reactions were evaluated after two weeks therapy of Gastropylor Complex Capsules. The height and weight of children were measured. The diet investigation was also included. Results: A total of 163 children were enrolled into the study, including 66 cases with postprandial distress syndrome (PDS) and 97 cases with epigastric pain syndrome (EPS). Compared to those in children with EPS, total symptom score increased (6.9±2.7 vs 3.6±1.7, t=5.90, P=0.00), while WAZ, WHZ, HAZ and dietary diversity score(DDS)decreased in PDS children before treatment (all P<0.05). The Gastropylor Complex Capsules were treated for 2 weeks, symptom improved in PDS, which from high to low is: anorexia > early satiety > abdominal pain > belch > nausea > abdominal distension. WAZ, WHZ and DDS increased in PDS children (all P<0.05). No significant drug -related adverse reaction was found during the study. Conclusion: Gastropylor Complex Capsules can improve the functional dyspepsia symptoms significantly, such as anorexia, early satiety, abdominal pain, abdominal distension, etc. The same efficacy was also in nutritional and dietary diversity in PDS children. No obvious drug -related adverse reaction is observed. |
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