| 秦 勇,许文杰,周一心,凌雪辉,王琦伟,詹 青.补肾活血疏肝汤联合西药治疗帕金森伴睡眠障碍及抑郁的疗效分析[J].,2019,19(21):4173-4175 |
| 补肾活血疏肝汤联合西药治疗帕金森伴睡眠障碍及抑郁的疗效分析 |
| Analysis of the Clinical Efficacy of Bushen Huoxue Shugan Decoction Combined with Western Medicine in the Treatment of Parkinson's Disease Patients with Sleep Disorders and Depression |
| 投稿时间：2019-07-28 修订日期：2019-08-23 |
| DOI：10.13241/j.cnki.pmb.2019.21.039 |
| 中文关键词: 补肾活血疏肝汤 帕金森 睡眠障碍 抑郁 非运动症状 |
| 英文关键词: Bushen Huoxue Shugan decoction Parkinson's disease Sleep disorder Depression Non-motor symptoms |
| 基金项目:上海市卫生和计划生育委员会中医药科研专项课题(2016LQ012)；上海市浦东新区领先人才项目(PWRl2016-02) |
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| 中文摘要: |
| 摘要 目的：探讨补肾活血疏肝汤联合西药治疗帕金森(PD)伴睡眠障碍及抑郁的临床疗效。方法：选择2016年1月~2018年1月上海中医药大学附属第七人民医院神经内科收治的210例PD伴睡眠障碍及抑郁患者，根据随机数字表法将患者分为联合组和对照组，每组各105例。对照组采用常规西医治疗，治疗组在此基础上加用补肾活血疏肝汤。治疗3个月后，评价和比较两组的总体疗效、治疗前后UPDRSⅡ、Ⅲ评分、PSQI评分及HAMD评分的变化情况。结果：治疗后，联合组UPDRSⅡ、Ⅲ评分和HAMD评分均较治疗前显著下降，且明显低于对照组(P<0.05)；两组PSQI评分均较治疗前显著下降，且联合组PSQI评分显著低于对照组(P<0.05)。结论：补肾活血疏肝汤联合西药治疗PD伴睡眠障碍及抑郁可显著提高其临床疗效，改善患者的睡眠障碍及抑郁状态。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the efficay of Bushen Huoxue Shugan decoction combined with western medicine in the treat- ment of Parkinson's disease(PD) patients with sleep disorders and depression. Methods: 210 cases of PD patients with sleep disorders and depression who were treated in the department of neurology in the Seventh People's Hospital Affiliated to Shanghai University of Tradi- tional Chinese Medicine from January 2016 to January 2018 were selected. According to random number table, the patients were divided into two groups. The control group(n=105) was treated with conventional western medicine, while the combined group (n=105) was sup- plemented with Bushen Huoxue Shugan decoction on the basis of control group. After 3 months of treatment, the overall effect was eval- uated, and the improvement of sleep disorder and depression were compared between the two groups. Results: After treatment, the UP- DRS Ⅱ, Ⅲ score of combined group were significantly decreased compared with those before treatment, and which were significantly lower than those of the control group (P<0.05). The PSQI score of both groups after treatment showed a significant reduction compared with before treatment, the PSQI scorein of combined group was significantly lower than that in the control group(P<0.05). After treat- ment, the HAMD score of combined group dropped, and it was significantly lower than that of the control group(P<0.05). Conclusion: Bushen Huoxue Shugan decoction combined with western medicine can obviously enhance the clinical efficacy of PD patients with sleep disorders and depression, it can help to better delay the aggravation of clinical symptom, improve the sleep disorder and depression. |
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