| 杨 青,杨艳萍,屈 芳,高彩彩,徐小刚.复方丹参注射液联合阿奇霉素治疗小儿喘息性支气管炎的效果及对炎性因子的影响[J].,2019,19(21):4084-4087 |
| 复方丹参注射液联合阿奇霉素治疗小儿喘息性支气管炎的效果及对炎性因子的影响 |
| Efficacy of Compound Danshen Injection Combined with Azithromycin in the treatment of Children with Asthmatic Dronchitis and Its Effect on the Inflammatory Factors |
| 投稿时间：2019-04-07 修订日期：2019-04-29 |
| DOI：10.13241/j.cnki.pmb.2019.21.019 |
| 中文关键词: 复方丹参注射液 阿奇霉素 小儿 喘息性支气管炎 炎性因子 |
| 英文关键词: Compound Danshen injection Azithromycin Children Asthmatic bronchitis Inflammatory factors |
| 基金项目:国家卫生计生委医药卫生科技发展中心项目(W2016CWQT33) |
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| 中文摘要: |
| 摘要 目的：探讨复方丹参注射液联合阿奇霉素治疗小儿喘息性支气管炎的效果及对炎性因子的影响。方法：选取2015年6月~2018年6月我院收治的喘息性支气管炎患儿300例，采用随机数字表法将患儿分为两组，每组各150例。对照组在常规治疗的基础上给予阿奇霉素注射液治疗，观察组在对照组的基础上联合应用复方丹参注射液治疗。比较两组的临床治疗效果，临床症状缓解时间及住院时间，治疗前后两组血清白介素（Interleukin, IL）-6、IL-8和肿瘤坏死因子-α( Tumor necrosis factor-α, TNF-α)水平的变化情况及不良反应发生情况和复发率。结果：治疗后，观察组治疗总有效率显著高于对照组（93.33% VS.85.33%, P＜0.05）；观察组喘息缓解时间、咳嗽缓解时间、哮鸣音消失时间、体温恢复时间及住院时间均显著短于对照组(P＜0.05)；两组治疗后血清IL-6、IL-8和TNF-α水平均较治疗前显著下降，且观察组更低(P＜0.05)；两组不良反应发生率比较差异无统计学意义(P＞0.05)，观察组的复发率显著低于对照组(P＜0.05)。结论：复方丹参注射液联合阿奇霉素可快速缓解喘息性支气管炎患儿的临床症状、体征并缩短住院时间，提高临床治疗效果，且复发率低，安全性较高，这可能与其可显著降低患儿血清IL-6、IL-8和TNF-α水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effeicacy of compound Danshen injection combined with Azithromycin in the treatment of children with asthmatic bronchitis and its effect on the inflammatory factors. Methods: 300 children with asthmatic bronchitis admitted to our hospital from June 2015 to June 2018 were randomly divided into two groups with 150 cases in each group. The control group was treated with Azithromycin injection on the basis of conventional treatment, and the observation group was treated with compound Danshen injection on the basis of the control group. The clinical treatment effect, relief time of clinical symptom and hospitalization time, and the changes of serum IL-6, IL-8 and TNF-α before and after treatment as well as the incidence and recurrence rate of adverse reactions were compared between the two groups. Results: After treatment, the total effective rate of observation group was significantly higher than that of the control group (93.33% vs. 85.33%, P<0.05). The time of wheezing remission, cough remission, asthma disappearance, temperature recovery and hospitalization in the observation group were significantly shorter than in the control group (P<0.05). The levels of serum IL-6, IL-8 and TNF-α in the two groups were significantly lower than those before treatment, and the observation group was lower (P<0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P>0.05), and the recurrence rate in the observation group was significantly lower than that in the control group (P<0.05). Conclusion: Compound Danshen injection combined with Azithromycin can rapidly relieve the clinical symptoms and signs of children with asthmatic bronchitis and shorten the hospitalization time, improve the clinical treatment effect, with a low recurrence rate and high safty, which may be related to the significantly decrease of serum IL-6, IL-8 and TNF- levels. |
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