| 杨 迅,宗 晔,焦 月,李 巍,俞 力,张澍田.内镜黏膜下剥离术治疗早期胃癌的疗效及对患者预后和血清抗凋亡因子、表皮生长因子的影响[J].,2019,19(21):4045-4048 |
| 内镜黏膜下剥离术治疗早期胃癌的疗效及对患者预后和血清抗凋亡因子、表皮生长因子的影响 |
| Efficacy of Endoscopic Submucosal Dissection for Early Gastric Cancer and Its Influence on Prognosis, Serum Anti-apoptotic Factor and Epidermal Growth Factor |
| 投稿时间：2019-02-28 修订日期：2019-03-23 |
| DOI：10.13241/j.cnki.pmb.2019.21.010 |
| 中文关键词: 内镜黏膜下剥离术 早期 胃癌 疗效 预后 抗凋亡因子 表皮生长因子 |
| 英文关键词: Endoscopic submucosal dissection Early Gastric cancer Efficacy Prognosis Serum anti-apoptotic factor Epidermal growth factor |
| 基金项目:北京市科技计划项目（Z171100004517009） |
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| 中文摘要: |
| 摘要 目的：探讨内镜黏膜下剥离术（ESD）治疗早期胃癌（EGC）的疗效及对患者预后和血清抗凋亡因子（Livin）、表皮生长因子（EGF）的影响。方法：选取我院于2014年1月~2015年12月期间收治的EGC患者98例为研究对象，根据随机数字表法将患者分为对照组（n=32）和研究组（n=66），对照组给予腹腔镜微创手术治疗，研究组患者给予ESD治疗，比较两组患者术后临床指标，比较两组患者手术前后血清Livin、EGF水平，观察两组患者术中及术后并发症发生情况，随访2年，记录两组患者随访期间的生存率及复发率。结果：研究组患者手术时间、住院时间均较对照组短，住院费用、术中出血量均较对照组少（P<0.05），但两组患者整块切除率、治愈性切除率比较差异无统计学意义（P>0.05）。两组患者术后血清Livin、EGF水平均较术前降低，且研究组低于对照组（P<0.05）。研究组术中及术后并发症总发生率为3.03%（2/66），低于对照组的15.63%（5/32）（P<0.05）。两组患者随访期间生存率、复发率比较无统计学差异（P>0.05）。结论：ESD治疗EGC的预后效果与腹腔镜微创手术相当，但其能够更有效地降低血清Livin、EGF水平，加快患者的恢复，并发症少，临床应用价值较高。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the efficacy of endoscopic submucosal dissection (ESD) in the treatment of early gastric cancer (EGC) and its influence on prognosis, serum anti-apoptotic factor (Livin) and epidermal growth factor (EGF). Methods: 98 patients with EGC who were admitted to our hospital from January 2014 to December 2015 were selected as the research objects.According to the digital table method, the patients were randomly divided into control group (n=32) and research group (n=66). The control group received laparoscopic minimally invasive surgery, and the research group was given ESD treatment. The clinical indicators of the two groups were compared. The serum levels of Livin and EGF were compared before and after operation. The complications during and after operation were observed. The two groups were followed up for 2 years. The survival rate and recurrence rate were observed. Results: The operation time and hospitalization time of the research group were shorter than those of the control group, and the hospitalization expenses and intraoperative bleeding volume were less than those of the control group (P<0.05), but there were no significant differences in the total resection rate and the cure resection rate between the two groups (P>0.05). The levels of serum Livin and EGF in both groups were lower than those before operation, and the level of Livin and EGF in the research group was lower than those in the control group (P<0.05). The total incidence rate of intraoperative and postoperative complications in the research group was 3.03%(2/66), which was significantly lower than that in the control group 15.63%（5/32）(P<0.05). There were no significant differences in survival rate and recurrence rate between the two groups during the follow-up period (P>0.05). Conclusion: The prognostic effect of ESD on EGC is similar to that of laparoscopic minimally invasive surgery, but it can effectively reduce the level of serum Livin and EGF, accelerate the recovery of patients, reduce complications, and have high clinical value. |
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