| 闫丽丽,吕 骥,贾红玉,徐梅梅,姜东春,吕 喆,邢志书.非酒精性脂肪性肝合并2型糖尿病患者血清chemerin水平变化及其相关性分析[J].,2019,19(20):3968-3972 |
| 非酒精性脂肪性肝合并2型糖尿病患者血清chemerin水平变化及其相关性分析 |
| Changes of Serum Chemerin Levels in Patients with Non-alcoholic Fatty Liver Disease and Type 2 Diabetes Mellitus and Their Correlation Analysis |
| 投稿时间：2019-06-01 修订日期：2019-06-23 |
| DOI：10.13241/j.cnki.pmb.2019.20.038 |
| 中文关键词: 非酒精性脂肪性肝 2型糖尿病 chemerin 相关性 |
| 英文关键词: Non-alcoholic fatty liver disease Type 2 diabetes Chemerin Correlation |
| 基金项目:河北省医学科学研究计划项目（2017HB013）；秦皇岛市科学技术研究与发展计划项目（201502A171） |
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| 中文摘要: |
| 摘要 目的：探讨非酒精性脂肪性肝（NAFLD）合并2型糖尿病患者血清chemerin水平变化及其相关性，为其临床诊治提供参考。方法：选择河北医科大学附属秦皇岛市第一医院收治的NAFLD和2型糖尿病患者作为研究对象，其中NAFLD合并2型糖尿病患者100例（A组），单纯NAFLD患者100例（B组），单纯2型糖尿病患者100例（C组），并选取同期来该院检查的100例健康人作为对照组。比较各组患者的血清chemerin、空腹血糖、胰岛素水平、肝功能、炎症因子、应激反应指标以及胰岛素抵抗指数（HOMA-IR）差异，分析血清chemerin水平与各项指标的相关性。结果：按照A组、B组、C组以及对照组的顺序，患者血清chemerin、谷氨酸氨基转移酶（ALT）、天冬氨酸氨基转移酶（AST）、肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）、丙二醛（MDA）、空腹血糖、胰岛素及HOMA-IR水平逐渐降低，而血清超氧化物歧化酶（SOD）以及谷胱甘肽过氧化物酶（GSH）水平逐渐升高，组间比较差异具有统计学意义（P<0.05）。经Pearson相关性分析，血清chemerin水平与血清ALT、AST、MDA、CRP、TNF-α、空腹血糖、胰岛素水平及HOMA-IR水平呈现正相关，与SOD、GSH水平呈现负相关（P<0.05）。结论：血清chemerin水平可通过对胰岛素抵抗、应激反应以及炎症反应等机制进行调节，参与NAFLD合并2型糖尿病的发生以及发展，并具有较好的相关性，可为NAFLD合并2型糖尿病患者的临床治疗提供新的突破点。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the changes and correlation of serum chemerin level in patients with nonalcoholic fatty liver disease (NAFLD) and type 2 diabetes mellitus, and to provide reference for clinical diagnosis and treatment. Methods: NAFLD and type 2 diabetes mellitus patients admitted to Qinhuangdao First Hospital Affiliated to Hebei Medical University were selected as the research objects. Among them, 100 patients with NAFLD and type 2 diabetes mellitus (group A), 100 patients with simple NAFLD (group B), 100 patients with simple type 2 diabetes mellitus (group C), and 100 healthy persons who came to the hospital for examination during the same period were selected as the control group. The differences of serum chemerin, fasting blood glucose, insulin level, liver function, inflammatory factors, stress response index and homeostasis model assessment insulin resistance index (HOMA-IR) of patients in each group were compared, and the correlation between serum chemerin level and each index was analyzed. Results: According to the order of group A, group B, group C and control group, the serum chemerin, alanine aminotransferase (ALT), aspartate aminotransferase (AST), tumor necrosis factor-α (TNF-α), C reactive protein (CRP), malondialdehyd (MDA), fasting blood sugar, insulin and HOMA-IR levels of the patients gradually decreased, while the serum superoxide dismutase (SOD) and glutathione peroxidas (GSH) levels gradually increased, with statistically significant differences(P<0.05). According to Pearson correlation analysis, serum chemerin level was positively correlated with serum ALT, AST, MDA, CRP, TNF-α, fasting blood sugar, insulin and HOMA-IR level, but negatively correlated with SOD and GSH level (P<0.05). Conclusion: Serum chemerin level can be regulated by insulin resistance, stress response and inflammation reaction. It can participate in the occurrence and development of NAFLD with type 2 diabetes mellitus, and has a good correlation. It can provide a new breakthrough point for the clinical treatment of NAFLD with type 2 diabetes mellitus. |
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