| 邢 云,张红侠,张力鑫,靳 芳,菅玉红,张静静,韩 康.不同血液净化方式对中毒所致多器官功能障碍的临床效果比较[J].,2019,19(20):3920-3924 |
| 不同血液净化方式对中毒所致多器官功能障碍的临床效果比较 |
| Analysis of Therapeutic Effect of Different Blood Purifications on Multiple Organ Dysfunction Syndrome Caused by Poisoning |
| 投稿时间：2019-04-01 修订日期：2019-04-27 |
| DOI：10.13241/j.cnki.pmb.2019.20.027 |
| 中文关键词: 中毒 序贯性血液净化 多器官功能障碍综合征 |
| 英文关键词: Poisoning Multiple organ dysfunction syndrome Sequential blood purification |
| 基金项目:国家自然科学基金项目(81702935)；济南军区总医院院长基金项目(2015ZX01) |
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| 中文摘要: |
| 摘要 目的：探讨两种不同的血液净化方式对中毒所致的多器官功能障碍综合征(multiple organ dysfunction syndrome，MODS)的临床治疗效果。方法：回顾性分析2015年9月至2018年9月我院收治的41例中毒所致的多器官功能障碍综合征患者，按照采取血液净化方式的不同将其分为实验组(序贯性净化)和对照组(单种净化)。比较两组患者在住院期间的一般住院指标(住院时间、费用等)及治疗后的主要血液指标、APACHE II (acute physiology and chronic health evaluation Ⅱ)评分和生存率。结果：治疗后第5天，实验组的丙氨酸氨基转移酶（ALT）、天门冬氨酸氨基转移酶（AST）等生化指标显著低于对照组(P<0.05)。治疗第5天时，实验组的APACHE II评分显著低于对照组 (P<0.05)，总住院费用高于对照组(P<0.05)，总住院时间及病死率与对照组比较差异无统计学差异(P>0.05)。结论：相对于单种血液净化方式而言，序贯性治疗可显著改善肝功指标，降低APACHE II评分，且不增加总住院时间，但增加了治疗费用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effect and safety of different blood purifications on the patients with multiple organ dysfunction syndrome caused by poisoning. Methods: From September 2015 to September 2018, 41 patients diagnosed as multiple organ dysfunction syndrome caused by poisoning were retrospectively analyzed. All the patients were divided into two groups by different blood purifications: experimental group (sequential blood purification group) or control group (single blood purification group). The clinical outcomes were evaluated by general situation(hospitalization time and hospitalization costs) and main blood indicators, APACHE Ⅱ score and survival rates after treatment. Results: Compared with the control group, the ALT, AST, CK-MB, LDH, Cr, Bun levels and APACHE Ⅱ score of treatment group were significantly lower than those of the control group after 5 days of treatment(P<0.05). The hospitalization cost of treatment group was higher than taht of the control group(P<0.05), while the length of hospital stay and the mortality of treatment group showed no significant difference between two groups(P>0.05). Conclusion: Compared with the single mode of blood purification, sequential therapy can significantly improve the hepatic function, reduce the APACHE II score for poisoning MODS, though it is more expensive, it won't increase the hospitalization time. |
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