| 李 莉,童明辉,张薇薇,林志艳,刘 璐,孙勇强.超声对早期糖尿病肾病的诊断价值及肾动脉血流阻力指数与血清hs-CRP、VEGF的关系分析[J].,2019,19(20):3862-3865 |
| 超声对早期糖尿病肾病的诊断价值及肾动脉血流阻力指数与血清hs-CRP、VEGF的关系分析 |
| Diagnostic Value of Ultrasonography in Early Diabetic Nephropathy and the Relationship Analysis between Renal Arterial Blood Flow Resistance Index and Serum hs-CRP and VEGF |
| 投稿时间：2019-04-04 修订日期：2019-04-28 |
| DOI：10.13241/j.cnki.pmb.2019.20.014 |
| 中文关键词: 早期 糖尿病肾病 彩色多普勒超声 诊断 肾动脉血流阻力指数 超敏C反应蛋白 血管内皮生长因子 |
| 英文关键词: Early Diabetic nephropathy Color doppler ultrasound Diagnostic Renal arterial blood resistance index Hypersensitive c-reactive protein Vascular endothelial growth factor |
| 基金项目:甘肃省教育厅高等学校科研项目（2015A-103）；2014甘肃中医药大学中青年基金（ZQ2014-19）；2018年甘肃中医药大学校级培育团队项目（甘中医大教发-2018-72）； 2018年甘肃省高等学校引进和使用国内外优质在线开放课程项目（甘教高-2018-13）；2017年甘肃省高等学校特色专业项目（甘高教2017-44） |
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| 中文摘要: |
| 摘要 目的：研究彩色多普勒超声对早期糖尿病肾病的诊断价值及肾动脉血流阻力指数与血清超敏C反应蛋白（hs-CRP）、血管内皮生长因子（VEGF）的关系。方法：选取从2017年2月～2018年2月兰州大学第二医院收治的早期糖尿病肾病患者50例记为病变组，另取同期于该院进行体检的健康人员50例记为对照组。分别对两组人员进行彩色多普勒超声检查，比较肾血流参数。采用酶联免疫吸附法检测两组人员血清hs-CRP、VEGF水平，并作指标间的相关性分析。结果：病变组肾主动脉、肾锥体两侧叶间动脉、肾段动脉的收缩期峰值速度、舒张期最低速度较对照组降低，病变组肾主动脉、肾锥体两侧叶间动脉、肾段动脉的阻力指数较对照组升高（均P＜0.05）。病变组血清hs-CRP、VEGF水平较对照组升高（均P＜0.05）。经Pearson相关性分析显示：早期糖尿病肾病患者肾主动脉、肾锥体两侧叶间动脉、肾段动脉的血流阻力指数与血清hs-CRP、VEGF均呈正相关关系（均P＜0.05）。结论：彩色多普勒超声应用于早期糖尿病肾病的诊断价值较高，且肾动脉血流阻力指数与血清hs-CRP、VEGF密切相关，临床工作中通过联合检测血清hs-CRP、VEGF，从而有助于早期糖尿病肾病的诊断。 |
| 英文摘要: |
| ABSTRACT Objective: To study the diagnostic value of color doppler ultrasound in early diabetic nephropathy and the relationship between renal arterial blood flow resistance index, serum hypersensitive c-reactive protein (hs-CRP) and vascular endothelial growth factor (VEGF). Methods: 50 cases of patients with early diabetic nephropathy who were admitted to Second Hospital of Lanzhou University from February 2017 to February 2018 were selected as the lesion group, and another 50 cases of healthy personnel who underwent physical examination in the hospital during the same period were selected as the control group. The two groups were examined by color Doppler ultrasound. Renal blood flow parameters were compared. The serum hs-CRP and VEGF levels in the two groups were detected by enzyme-linked immunosorbent assay, and the correlation between the indexes was analyzed. Results: The systolic peak velocity and diastolic minimum velocity of the renal aorta, bilateral interlobular arteries of renal pyramid and renal segmental arteries in the lesion group were lower than those in the control group. The resistance indexes of the renal aorta, bilateral interlobular arteries of renal pyramid and renal segmental arteries in the lesion group were higher than those in the control group (all P<0.05). Serum hs-CRP and VEGF levels in the lesion group were higher than those in the control group (all P<0.05). Pearson correlation analysis showed that the blood flow resistance indexes of the renal aorta, bilateral interlobular arteries of renal pyramid and renal segmental arteries in patients with early diabetic nephropathy were positively correlated with serum hs-CRP and VEGF (all P<0.05). Conclusion: The application of color doppler ultrasound in the diagnosis of early diabetic nephropathy has high value, and renal arterial blood resistance index is closely related to serum hs-CRP and VEGF. In clinical work, serum hs-CRP and vascular endothelial growth factor can be detected jointly, which is helpful for the diagnosis of early diabetic nephropathy. |
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