| 齐凤丽,房 芹,李明军,高艳琨,牛献谊,于佳丽.复方苦参注射液联合盐酸羟考酮缓释片治疗卵巢癌患者癌痛的临床研究[J].,2019,19(19):3730-3733 |
| 复方苦参注射液联合盐酸羟考酮缓释片治疗卵巢癌患者癌痛的临床研究 |
| A Clinical Study on Compound Kushen Injection Combined with Hydroxycodone Hydrochloride Sustained Release Tablet in the Treatment of Ovarian Cancer Patients with Cancer Pain |
| 投稿时间：2019-01-30 修订日期：2019-02-26 |
| DOI：10.13241/j.cnki.pmb.2019.19.030 |
| 中文关键词: 盐酸羟考酮缓释片 复方苦参注射液 卵巢癌 癌痛 生活质量 |
| 英文关键词: Oxycodone hydrochloride sustained-release tablets Compound Kushen injection Ovarian cancer Cancer pain Life quality |
| 基金项目:内蒙古自治区自然科学基金项目(2017MS0868) |
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| 中文摘要: |
| 摘要 目的：探讨盐酸羟考酮缓释片联合复方苦参注射液对卵巢癌患者癌痛的影响。方法：选择我院2015年1月至2018年6月收治的77例卵巢癌患者，随机分为观察组(39例)及对照组(38例)。对照组给予羟考酮缓释片，观察组在对照组基础上加用复方苦参注射液，对比两组治疗前和治疗1个疗程后的疼痛数字评分(Numerical rating scale，NRS)评分和生活质量评分的变化，治疗期间每人每天的羟考酮用量及不良反应的发生情况。结果：治疗后，两组NRS评分均较治疗前明显下降，且观察组NRS评分明显低于对照组(P<0.05)。治疗后，观察组的疲乏、恶心呕吐、疼痛、食欲丧失、便秘评分明显低于对照组(P<0.05)。观察组每人每天羟考酮的用量、便秘及不良反应总发生率明显低于对照组(P<0.05)。结论：复方苦参注射液联合羟考酮可有效缓解卵巢癌的癌痛，降低羟考酮毒副作用，提高患者的生活质量。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of hydroxycodone hydrochloride sustained release tablet combined with compound kushen injection on the cancer pain in patients with ovarian cance. Methods: 77 cases of patients with ovarian cancer from Jan. 2015 to June 2018 in our hospital were chosen and randomly divided into the observation group (39 cases) and the control group(38 cases). The control group was given hydroxycodone hydrochloride sustained release tablet, the observation group was given compound kushen injection on the basis of the control group. The changes of NRS score and quality of life before and after 1 course of treatment, the amount of oxycodone per person per day and the occurrence of adverse reactions during the treatment were compared between two groups. Results: After treatment, the NRS scores of both groups were significantly lower than those before treatment, and the NRS score of observation group was significantly lower than that of the control group (P<0.05). After treatment, the scores of fatigue, nausea and vomiting, pain, loss of appetite and constipation in the observation group were significantly lower than those in the control group (P<0.05). The daily dose of oxycodone, constipation and total incidence of adverse reactions in the observation group were significantly lower than those in the control group(P<0.05). Conclusion: Compound Kushen injection combined with oxycodone could effectively alleviate the cancer pain of ovarian cancer, reduce the side effects of oxycodone and improve the patients' quality of life. |
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