| 雷 琦,陈晓莉,李 鹏,王 涛,杨 谦.氯吡格雷用于缺血性脑卒中的疗效评价及对血小板活性及血清炎症因子水平的影响[J].,2019,19(19):3670-3673 |
| 氯吡格雷用于缺血性脑卒中的疗效评价及对血小板活性及血清炎症因子水平的影响 |
| Efficacy of Clopidogrel in the Treatment of Ischemic Stroke and Its Effect on the Platelet Activity and Serum Inflammatory Factors Levels |
| 投稿时间：2019-04-10 修订日期：2019-04-30 |
| DOI：10.13241/j.cnki.pmb.2019.19.016 |
| 中文关键词: 缺血性脑卒中 氯吡格雷 血小板活性 炎症因子 |
| 英文关键词: Ischemic stroke Clopidogrel Platelet activity Inflammatory cytokines |
| 基金项目:陕西省重点研发计划项目(2017SF-289) |
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| 中文摘要: |
| 摘要 目的：评价氯吡格雷用于缺血性脑卒中的疗效及对血小板活性及血清炎症因子水平的影响。方法：选择我院2016年8月~2018年8月收治的150例缺血性脑卒中患者，按入院先后顺序分为对照组(83例)和研究组(67例)。对照组采用常规治疗，研究组在对照组基础上联合氯吡格雷治疗，比较两组的临床疗效，治疗前后血小板活性指标，血清超敏-C反应蛋白(hypersensitive c-reactive protein，hs-CRP)、白介素-6(Interleukin-6，IL-6)及肿瘤坏死因子-α(Tumor necrosis factor-α，TNF-α)水平，美国国立卫生研究院卒中量表(National Institutes HealthStroke Scale，NIHSS)和日常生活活动能力(Activity of daily living，ADL)评分的变化和不良反应的发生情况。结果：治疗后，研究组总有效率显著高于对照组(91.04% vs. 78.31%，P<0.05)；两组血小板聚集率、血小板黏附率、P选择素、hs-CRP、IL-6、TNF-α及NIHSS评分均较治疗前明显下降，且研究组以上指标均显著低于对照组，两组ADL评分均较治疗前显著上升，且研究组明显高于对照组(P<0.05)。两组治疗期间不良反应总发生率比较差异无统计学意义(P>0.05)。结论：氯吡格雷用于缺血性脑卒中的效果明显优于常规治疗，其能够有效抑制血小板活性、降低炎症因子水平、改善患者神经功能和日常生活能力。 |
| 英文摘要: |
| ABSTRACT Objective: To evaluate the efficacy of clopidogrel in the treatment of ischemic stroke and its effect on the platelet activity and serum inflammatory factor levels. Methods: 150 patients with ischemic stroke who were treated from August 2016 to August 2018 in our hospital were divided into control groups(83 cases) and research group(67 cases) according to the order of admission. The control group was treated with conventional therapy, and the research group was treated with clopidogrel on the basis of control group. Then the clinical efficacy, changes of platelet activity index, serum hypersensitive c-reactive protein (hs-CRP), interleukin-6 (IL-6), tumor necrosis factor-α(TNF-α) levels, National Institutes Health Stroke Scale (NIHSS) and the activity of daily living (ADL) scores before and after treatment and the poor reaction occurrence were compared between two groups. Results: After treatment, the total effective rate in the research group was significant higher than that in the control group(91.04% vs. 78.31%, P<0.05). The platelet aggregation rate, platelet adhesion rate, p-selectin, hs-CRP, IL-6, TNF-?琢 and NIHSS scores in both groups were significantly decreased after treatment compared with those before treatment,the above indexes in the research group were significantly lower than those in the control group, the ADL scores of both groups were significantly higher than those before treatment, which were significantly higher in the research group than those of the control group(P<0.05). There was no statistically significant difference in the total incidence of adverse reactions between the two groups during treatment (P>0.05). Conclusion: The effect of clopidogrel on ischemic stroke is obviously better than that of conventional treatment, it can effectively inhibit the activity of platelets, reduce the level of inflammatory factors, and improve the neurological function and daily life ability of patients. |
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