| 袁 峰,韩 曦,陈晓鹏,胡 盈,王亚琴.维生素E联合尼莫地平治疗妊娠期高血压综合征的效果观察[J].,2019,19(18):3523-3526 |
| 维生素E联合尼莫地平治疗妊娠期高血压综合征的效果观察 |
| Effect of Vitamin E Combined with Nimodipine in the Treatment of Pregnancy Induced Hypertension Syndrome |
| 投稿时间：2019-05-07 修订日期：2019-05-29 |
| DOI：10.13241/j.cnki.pmb.2019.18.027 |
| 中文关键词: 维生素E 尼莫地平 妊娠期高血压综合征 皮质醇 和肽素 血管内皮功能 |
| 英文关键词: Vitamin E Nimodipine Pregnancy induced hypertension syndrome Cortisol Peptide Vascular endothelial function |
| 基金项目:陕西省缺血性心血管疾病重点实验室项目(18JS103) |
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| 中文摘要: |
| 摘要 目的：研究维生素E联合尼莫地平治疗妊娠期高血压综合征的临床效果和可能机制。方法：选择2016年1月～2018年12月我院收治的200例妊娠期高血压综合征患者并将其随机分为两组。对照组患者口服维生素E治疗，每次50 mg，每天3次；观察组联合口服尼莫地平治疗，每次30 mg，每天2次。检测和比较两组治疗前后的血清肽素、皮质醇、一氧化氮及内皮素、血清C反应蛋白(C-reactive protein, CRP)、白介素-12(Interleukin-12, IL-12)和肿瘤坏死因子-α(Tumor necrosis factor-alpha, TNF-α)水平的变化，记录患者的妊娠结局：胎盘早剥、产后出血、胎儿窘迫、剖宫产、低体重儿以及新生儿窒息的发生情况。结果：治疗后，观察组的总有效率明显高于对照组(91% vs. 73%，P<0.05)；两组的血清肽素、皮质醇及内皮素水平均较治疗前明显降低，血清一氧化氮水平较治疗前明显升高，且观察组的以上指标水平均明显优于对照组(均P<0.05)。两组治疗后的血清CRP、IL-12和TNF-α水平均较治疗前明显降低，且观察组以上指标均明显低于对照组(均P<0.05)。观察组的胎盘早剥率、产后出血率、胎儿窘迫率、剖宫产率、低体重儿率以及新生儿窒息率均明显低于对照组(P<0.05)。结论：维生素E联合尼莫地平能明显改善妊娠期高血压综合征的妊娠结局，可能与其降低血清CRP、IL-12、TNF-α、皮质醇及和肽素水平有关。 |
| 英文摘要: |
| ABSTRACT Objective: To study the clinical effect and possible mechanism of vitamin E combined with nimodipine in the treatment of pregnancy-induced hypertension syndrome. Methods: 200 patients with pregnancy-induced hypertension syndrome who were treated in our hospital from January 2016 to December 2018 were randomly divided into two groups. The control group was given oral vitamin E treatment, 50 mg each time, three times a day, the observation group was treated with oral nimodipine, 30 mg each time, twice a day. The changes of serum copeptin, cortisol, NO and endothelin, CRP, IL-12 and TNF-α levels before and after treatment were detected and compared between the two groups. And the pregnancy outcome: placental abruption, postpartum hemorrhage, fetal distress, cesarean section, low birth weight and neonatal asphyxia were recorded. Results: After treatment, the total effective rate of observation group was significantly higher than that of the control group (91% vs. 73%, P<0.05). After treatment, the levels of serum peptide, cortisol and endothelin in the two groups were significantly lower than those of the control group, while the levels of serum nitric oxide were significantly higher, and the above indicators in the observation group were significantly better than those of the control group (both P<0.05). After treatment, the levels of serum CRP, IL-12 and TNF-α in the two groups were significantly decreased , and the the above indexes in the observation group were significantly lower than those in the control group (all P<0.05). The rates of placental abruption, postpartum hemorrhage, fetal distress, cesarean section, low birth weight and neonatal asphyxia in the observation group were significantly lower than those in the control group (P<0.05). Conclusion: Vitamin E combined with nimodipine can significantly improve the pregnancy outcome of hypertensive syndrome in pregnancy, it may be related to the decrease of serum CRP, IL-12 and TNF-α, cortisol, peptide, and levels. |
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