| 谷 越,陈 刚,张 杨,赵金璐,明晓冬,高梅鷟.胃癌患者发病部位、发病年龄以及临床病理特征之间的关系[J].,2019,19(16):3119-3123 |
| 胃癌患者发病部位、发病年龄以及临床病理特征之间的关系 |
| The Relationship Among the Location, Age and Clinicopathologic Features of Gastric Cancer Patients |
| 投稿时间：2018-11-08 修订日期：2018-11-29 |
| DOI：10.13241/j.cnki.pmb.2019.16.023 |
| 中文关键词: 胃癌 部位 年龄 性别 病理 |
| 英文关键词: Gastric cancer Pathology Age Gender |
| 基金项目:黑龙江省自然科学基金项目(D201250) |
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| 中文摘要: |
| 摘要 目的：探讨胃癌患者发病部位、发病年龄年龄以及临床病理特征之间的关系。方法：选取2008年1月~2017年12月哈医大一院及哈医四院普外科经手术治疗的1200例胃癌患者，对其发病部位、发病年龄与性别、肿瘤大小、Borrmann分型、大体分型、病理分化类型等情况进行统计学分析。结果：在113例早期胃癌患者中，60例发病部位在胃窦小弯部，占53.1%；胃体小弯部29例，占25.7%；胃角部14例，12.4%；贲门部10例，占8.8%。不同发病部位患者性别构成比较差异存在明显的统计学意义(P<0.05)，但年龄、肿瘤大小、大体分型、病理分化类型比较差异无统计学意义(P>0.05)。在1087例进展期胃癌患者中，好发部位以胃窦部最多，为608例(55.9%)，其次是胃底贲门部249例(22.9%)和胃体部173(15.9%)。不同发病部位患者性别构成比较冲压存在明显的统计学意义(P<0.05)，而患者年龄、肿瘤大小、Borrmann分型、病理分化类型比较冲压无统计学意义(P>0.05)。在不同年龄组别胃癌患者的统计中，全组男女总比为2.3:1，在≦40岁组中男女比例为1.1:1，>40岁≦60岁组中男女比例为2.4:1，>60岁组中男女比例为2.9:1，三组对比(x2=8.39，P<0.05)存在明显统计学意义；在病理学分化类型的三组对比中，以低分化腺癌为主占91.7%，但随着年龄的增长，高分化腺癌比例有所增加(x2=16.74，P<0.05)存在明显统计学意义；而发病部位以胃下部1/3最多649例，占54.1%，三组对比无明显统计学意义；肿瘤大小以>2 cm≦5 cm最多567例，占47.3%，三组对比无明显统计学意义；Borrmann分型以BorrmannⅢ型最多594例，占49.5%，三组对比无明显统计学意义。结论：无论早期胃癌还是进展期胃癌，好发部位以胃窦小弯部最多；胃癌发病部位与性别存在一定关系，在早期胃癌中，发病部位越高，女性患者比例越大；在进展期胃癌中，胃癌发生的位置越高，男性比例越大；此外，胃癌患者年龄越小，女性比例越大；胃癌患者年龄越大，高、中分化腺癌的比例越大。胃癌患者的发病部位与临床病理特征无明显相关性。 |
| 英文摘要: |
| ABSTRACT Objective: To investigation the relationship among the location, age and clinicopathological features of gastric cancer patients. Methods: The clinical data for 1200 patients with gastric cancer in our hospital from Jan 2008 to Dec 2017 were analyzed with SPSS 24.0, including pathogenic sites, age, gender, tumor size, Borrmann type, general type and pathological differentiation type. For enumeration data, x2 test is used. Results: In 113 cases of early gastric cancer, Most of tumors occurred at lesser curvature of antrum (60, 53.1%); lesser curvature of corpus (29, 25.7%); angulus (14, 12.4%); cardia (10, 8.8%). In the four groups, there was significant difference between pathogenic sites and gender (x2=2.37, P<0.05). There was no significant difference with age, tumor size, general type and pathological differentiation type; In 1087 cases of adanced gastric cancer, The most predilection site was antrum (608, 55.9%)，secondly gastric fundus and cardia (249, 22.9%) and gastric body (173, 15.9%). In the four groups divided according to predilection site, there was significant difference with gender (x2=5.32, P<0.05). There was no significant difference with age, tumor size, Borrmann type, pathological differentiation type. The patients were divided into three groups (A: ≦40, B: >40≦60, C: >60) according to different ages, the total proportion of male and female was 2.3:1. The proportion of each group was 1.1:1, 2.4:1, 2.9:1. There was significant difference between the three groups (x2=8.39, P<0.05); Through the comparison for the three groups of pathology differentiation types, was 91.7% at most. However, the ratio of well differentiated adenocarcinoma increased as the growth of the age, which was statistical significance with poorly differentiated adenocarcinoma (x2=16.74, P<0.05). There was no significant difference in the pathogenic sites groups in which the cases of location at lower third of stomach was most (649, 54.1%). There was no significant difference in the tumor size groups in which the cases of size (>2 cm≦5 cm) was most (567, 47.3%). There was also no significant difference in Borrmann type groups in which the cases of BorrmannⅢ was most (509, 46.8%). Conclusion: No matter early gastric cancer or advanced gastric cancer,the most common site is the small curve side of the gastric antrum; in the early gastric cancer, the higher the lesion location , the greater the propotion of female patients; in the advanced gastric cancer, the higher the lesion location, the greater the propotion of male patients; in addition, the younger age of gastric cancer patients, the greater propotion of women; the older gastric caner patients are, the higher proportion of highly and moderately diferentiated adenocarcinoma is. No significant correlation was found between the location and clinicopathological features of gastric cancer. |
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