| 亚拉盖,图 雅,吉仁巴雅,杨 帆,赵 璇.血清NGF、BDNF、GFAP水平与老年血管性痴呆严重程度的相关性分析[J].,2019,19(14):2703-2706 |
| 血清NGF、BDNF、GFAP水平与老年血管性痴呆严重程度的相关性分析 |
| Correlative Analysis of Serum NGF, BDNF and GFAP Levels with the Severity of Senile Vascular Dementia |
| 投稿时间：2019-01-30 修订日期：2019-02-22 |
| DOI：10.13241/j.cnki.pmb.2019.14.021 |
| 中文关键词: 老年血管性痴呆 神经生长因子 脑源性神经营养因子 胶质纤维酸性蛋白 相关性 |
| 英文关键词: Senile vascular dementia Model NGF BDNF GFAP Correlation |
| 基金项目:内蒙古自治区自然科学基金项目(2016BS0315) |
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| 中文摘要: |
| 摘要 目的：探讨血清神经生长因子(Nerve Growth Factor， NGF)、脑源性神经营养因子(Brain Derived Neural Nutrition Factor, BDNF)、胶质纤维酸性蛋白(Glial Fibrillary Acidic Protein，GFAP)水平与老年血管性痴呆严重程度的相关性。方法：选择我院2016年1月至2018年12月收治的81例老年血管性痴呆患者，根据简易精神状态检查表(MMES)评分将其分为三组，以MMSE评分21~26分者为轻度组(26例)，10~20分者为中度组(28例)，0~9分者为重度组(27例)，同时选择来院体检的50例健康者作为对照组，检测和比较各组的血清NGF、BDNF、GFAP水平，分析血清NGF、BDNF、GFAP水平与老年血管性痴呆患者MMSE分值的相关性。结果：老年血管性痴呆者的血清NGF、GFAP水平明显高于对照组(P<0.05)，血清BDNF水平明显低于对照组(P<0.05)。轻度组、中度组、重度组的血清NGF、GFAP、BDNF水平对比差异均有统计学意义(P<0.05)：NGF水平：轻度组<中度组<重度组，BDNF水平：轻度组<中度组<重度组；GFAP水平：轻度组>中度组>重度组。血清NGF、BDNF水平与MMSE分值评分呈显著正相关(r1=0.652，r2=0.671，P<0.05)，血清GFAP水平与MMSE分值呈显著负相关(r3=-0.681，P<0.05)。结论：血清NGF、BDNF、GFAP水平均与老年血管性痴呆的严重程度密切相关，可能用于评估老年血管性痴呆病情的严重程度。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation of serum NGF(Nerve Growth Factor), BDNF(Brain Derived Neural Nutrition Factor) and GFAP(Glial Fibrillary Acidic Protein) levels with the severity of senile vascular dementia. Methods: 81 elderly patients with vascular dementia in our hospital from January 2016 to December 2018 were selected according to the MMSE score, all patients were divided into three groups according to the MMSE score: mild group (MMSE score: 21~26, 26 cases), moderate group (MMSE score: 10~20, 28 cases), and severe group (MMSE score: 0~9, 27 cases). 50 healthy patients were selected for the physical examination at the same time. The NGF, BDNF and GFAP levels in each group were detected and compared, and the correlation between serum NGF, BDNF and GFAP levels and MMSE scores in the elderly patients with vascular dementia was analyzed. Results: The serum NGF and GFAP levels of senile vascular dementia patients were significantly higher than those in the control group, and the serum BDNF levels were significantly lower than those in the control group(P<0.05). The NGF, GFAP and BDNF levels of the mild, moderate and severe groups were significantly different(P<0.05). NGF level: mild group < moderate group < severe group, BDNF level: mild group < moderate group < severe group; GFAP level: mild group > moderate group > severe group(P<0.05). The serum NGF and BDNF levels were positively correlated with MMSE scores(r1=0.652, r2=0.671, P<0.05), serum GFAP level was significantly negative correlated with MMSE score(r3=-0.681, P<0.05). Conclusion: The NGF, BDNF and GFAP levels in serum were closely related to the severity of senile vascular dementia, and which could be used to determine the severity of senile vascular dementia. |
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