| 辛向兵,熊延路,思 越,潘明宏,石明延,卢 强,李小飞,韩 勇.苹果酸-天冬氨酸穿梭关键酶和肺腺癌临床特征的相关性[J].,2019,19(14):2683-2686 |
| 苹果酸-天冬氨酸穿梭关键酶和肺腺癌临床特征的相关性 |
| Association between the Key Enzymes in Malate-aspartic Acid Shuttle and Clinical Features of Lung Adenocarcinoma |
| 投稿时间：2019-01-26 修订日期：2019-02-21 |
| DOI：10.13241/j.cnki.pmb.2019.14.016 |
| 中文关键词: 有氧糖酵解 苹果酸-天冬氨酸穿梭 肺腺癌 生存分析 天冬氨酸氨基转移酶2 |
| 英文关键词: Aerobic glycolysis Malic acid-aspartate shuttle Lung adenocarcinoma Survival analysis Aspartate aminotransferase 2 |
| 基金项目:国家自然科学基金项目(81772462) |
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| 中文摘要: |
| 摘要 目的：探讨苹果酸-天冬氨酸穿梭途径中的关键酶和肺腺癌临床特征的相关性。方法：首先从GEO数据库、TCGA平台中获取肺腺癌的转录组数据和相应的临床信息，通过非参数检验分析苹果酸脱氢酶1/2和天冬氨酸氨基转移酶1/2这四种关键酶在肿瘤组织和正常组织之间的表达差别，再进一步分析其和肺腺癌患者总生存期、人口学特征、TNM参数以及肿瘤恶性生物学标志物之间的关系。结果：肺腺癌中苹果酸脱氢酶1/2和天冬氨酸氨基转移酶1/2均呈高表达；天冬氨酸氨基转移酶2 (Glutamic-oxaloacetic transaminase 2，GOT2)和肺腺癌的生存概率有关，高表达GOT2的病人往往具有较短的总生存期；GOT2的表达和肺腺癌的人口学特征、TNM参数、临床分期均无明显统计学关联，与肿瘤恶性标志物PCNA呈显著正相关(r=0.2，P<0.05)。结论：肺腺癌组织中苹果酸-天冬氨酸穿梭途径中关键酶GOT2呈高表达，并可能促进肺腺癌的发生和恶性进展。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the correlation between the key enzymes in the malate-aspartate shuttle pathway and clinical features of lung adenocarcinoma. Methods: Firstly, the transcriptome data and corresponding clinical information of lung adenocarcinoma were obtained from GEO database and TCGA platform. Then nonparametric analysis was applied to evaluate expression difference of key enzymes (malate dehydrogenase 1/2 and aspartate aminotransferase 1/2) between the tumor tissue and the normal tissue. Furthermore, relationships between enzymes and clinical features like overall survival rate, demographic characteristics, TNM parameters and malignant biomarkers were investigated. Results: Malate dehydrogenase 1/2 and aspartate aminotransferase 1/2 were highly expressed in lung adenocarcinoma; Glutamic-oxaloacetic transaminase 2 (GOT2) was tightly correlated to survival probability of lung adenocarcinoma, where patients with high expression of GOT2 tended to have shorter overall survival time; There is no statistically significant association between GOT2 expression and demographic characteristics, TNM parameters, and clinical stage of lung adenocarcinoma; But correlation analysis exhibited positive correlation between GOT2 and the tumor malignant marker PCNA (r=0.2, P<0.05). Conclusion: GOT2, a key enzyme in the malate-aspartate shuttle pathway, was highly expressed in lung adenocarcinoma and may contribute to the initiation and malignant progression of lung adenocarcinoma. |
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