| 彭程飞,田孝祥,刘 丹,李 洋,赵 丽,赵 巍.人参皂苷Rg1促进大鼠急性心肌梗死后血管新生[J].,2019,19(14):2638-2641 |
| 人参皂苷Rg1促进大鼠急性心肌梗死后血管新生 |
| Ginsenoside-Rg1 Promotes the Myocardial Angiogenesis in Rat after Acute Myocardial Infarction |
| 投稿时间：2018-12-07 修订日期：2018-12-30 |
| DOI：10.13241/j.cnki.pmb.2019.14.007 |
| 中文关键词: 人参皂苷Rg1 急性心肌梗死 血管新生 |
| 英文关键词: Ginsenoside-Rg1 Acute myocardial infarction Angiogenesis |
| 基金项目:全军医学科技青年培育项目 (16QNP057)； 辽宁省博士启动基金项目(201601399； 201601405) |
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| 中文摘要: |
| 摘要 目的：明确人参皂苷Rg1在大鼠发生急性心肌梗死后是否能够促进心脏血管新生。方法：通过结扎SD大鼠左冠状动脉前降支建立大鼠急性心肌梗死模型，并将60只雄性SD大鼠随机分单纯手术组与人参皂苷Rg1治疗组。治疗组的大鼠造模1 h后将预先配成药液的人参皂甙Rgl按5 rag／(kg?d)剂量腹腔注射，1次/日至处死当日。对照组则腹腔注射等量生理盐水1次/日至处死当日。分别于手术后3、7天时对比两组大鼠的基本生命指标，后通过免疫荧光染色CD31对比观察两组大鼠心脏细胞中CD31的表达来评判血管新生水平。结果：①手术后3天、7天，两组大鼠的体重、心脏重量、心重/体重、鼠尾收缩压、心率比较差异均没有统计学意义(P>0.05)；②手术后3天、7天，人参皂苷Rg1治疗组心脏CD31表达水平明显高于对照组。结论：人参皂苷Rg1能够促进大鼠急性心肌梗后心脏的血管新生。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the promotion effects of Ginsenoside-Rg1 on angiogenesis of rat after acute myocardial infarction. Methods: Myocardial infarction was induced by making a knot to permanently occlude the left anterior descending coronary artery (LAD) of rat. The rats have been divided into two groups: the control and the Rg1. After 3 and 7 days of surgery, we compare the basic life index of the two group rats. Then the hearts of rat have been taken out. We investigate the cells morphological characteristics, myocardial basic institutions and angiogenesis by immunofluorescence staining. Results: ①We found that body weight(BW), heart weight(HW), HW/BW, Tail-cuff systolic blood pressure(TC-SBP) and heart rate(HR) have no difference between the control group and Rg1 group. ②Comparing the control group, we found that the heart has higher level of the CD31 expression after 3 days and 7days in Rg1 group. Conclusion: Ginsenoside-Rg1 can effectively promote angiogenesis of rat after acute myocardial infarction leading to prevent ventricular remodeling. |
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