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作者	单位	E-mail
陈苗苗	新疆维吾尔自治区中医医院干一科新疆乌鲁木齐 830000	cmm84918@163.com
孙敬雯	新疆维吾尔自治区中医医院干一科新疆乌鲁木齐 830000
洪　军	新疆维吾尔自治区中医医院干一科新疆乌鲁木齐 830000
王骁腾	新疆维吾尔自治区中医医院干一科新疆乌鲁木齐 830000
贾　佳	新疆维吾尔自治区中医医院干一科新疆乌鲁木齐 830000

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中文摘要:

摘要目的：探讨国医大师沈宝藩临床运用三十余年的化痰脉通片对高脂血症大鼠脂肪肝、肝功能的干预效果，了解其改善肝功能，治疗脂肪肝作用疗效。方法：选取SD大鼠75只，随机分为正常组、模型组、氟伐他汀组、化痰脉通中剂量组、化痰脉通高剂量组，每组15只，观察对比各组治疗后血脂水平、肝功能的变化，并通过病理切片，对比各组脂肪肝疗效。结果：正常组、氟伐他汀组、化痰脉通中剂量组、化痰脉通高剂量组总胆固醇（TC）、甘油三酯（TG）、低密度脂蛋白胆固醇（LDL-C）均显著低于模型组（P＜0.05），而高密度脂蛋白胆固醇（HDL-C）显著高于模型组（P＜0.05）；正常组及化痰脉通高剂量组TC、TG、LDL-C均显著低于化痰脉通中剂量组及氟伐他汀组（P＜0.05），而HDL-C显著高于化痰脉通中剂量组及氟伐他汀组（P＜0.05），且化痰脉通中剂量组及氟伐他汀组血脂水平无显著性差异（P＞0.05）；正常组TC、TG、LDL-C[（1.28±0.38）mmol/L，（0.40±0.16）mmol/L，（0.39±0.07）mmol/L]显著低于化痰脉通高剂量组[（5.18±1.42）mmol/L，（0.51±0.24）mmol/L，（2.07±0.46）mmol/L]（P＜0.05），而HDL-C[（3.78±0.34）mmol/L]显著高于化痰脉通高剂量组[（2.89±0.78）mmol/L]（P＜0.05）。正常组、氟伐他汀组、化痰脉通中剂量组、化痰脉通高剂量组丙氨酸转氨酶（ALT）、谷草转氨酶（AST）均显著低于模型组（P＜0.05）；正常组[（10.38±1.46）mmol/L，（10.85±1.24）mmol/L]、化痰脉通中剂量组[（15.97±3.64）mmol/L，（16.52±1.18）mmol/L]、化痰脉通高剂量组[（10.54±1.01）mmol/L，（10.62±1.67）mmol/L]AST、ALT均显著低于较氟伐他汀组[（25.47±2.38）mmol/L，（21.34±2.39）mmol/L]（P＜0.05），而组间AST、ALT比较无显著性差异，不具有统计学意义（P＞0.05）。在肝脏病理切片的对比中，随着化痰脉通片剂量的增加，脂肪肝的程度减轻。结论：化痰脉通片具有良好的降脂效果，且与剂量有关，其对肝功能具有良好的保护作用并对脂肪肝具良好的治疗作用，其治疗机制可能与调脂作用有关。

英文摘要:

ABSTRACT Objective: To investigate the effect of the Chinese medicine master Shen Baofan for more than thirty years in the treatment of fatty liver and liver function in hyperlipidemia rats with the effect of Huatan Mai Tong tablet on the function of fatty liver and liver in hyperlipidemia rats, and to understand the effect of improving the liver function and treating the effect of fatty liver. Methods: 75 SD rats were randomly divided into normal group, model group, fluvastatin group, middle dose group and high dose group of huatatsu Mai Tong, 15 rats in each group. The changes of blood lipid level and liver function after treatment were observed and compared, and the effect of fatty liver in each group was compared by pathological section. Results: The levels of TC, TG and LDL-C in high dose group of normal group, fluvastatin group, middle dose and high dose group of Huatan Maitong were lower than those in the model group (P<0.05), but the level of HDL-C was higher than that in the model group (P<0.05); the levels of TC, TG and LDL-C in the normal group and the high dose group were lower than those in the middle dose group and the fluvastatin group (P<0.05), but the level of HDL-C was higher than that in the middle dose group and the fluvastatin group (P<0.05), and there was no significant difference between the middle dose group and the fluvastatin group (P>0.05); TC, TG, LDL-C C[(1.28±0.38) mmol/L，(0.40±0.16) mmol/L，(0.39±0.07) mmol/L] in the normal group were significantly lower than those in the Huatan Maitong high dose group [(5.18±1.42) mmol/L，(0.51±0.24) mmol/L，(2.07±0.46) mmol/L] (P<0.05), while HDL-C[(3.78±0.34) mmol/L] was significantly higher than that in the Huatan Maitong high dose group [(2.89±0.78) mmol/L] (P<0.05). The level of AST and ALT in normal group, fluvastatin group, middle dose and high dose group of Huatan Mai Tong were lower than those in the model group (P<0.05); The AST and ALT of normal group [(10.38+1.46) mmol/L, (10.85+1.24) mmol/L], Huatan Maitong middle-dose group [(15.97+3.64) mmol/L, (16.52+1.18) mmol/L], and Huatan Maitong high-dose group [(10.54+1.01) mmol/L, (10.62+1.67) mmol/L] were significantly lower than those of fluvastatin group [(25.47+2.38) mmol/L, (21.34+2.39] respectively. Mmol/L] (P<0.05). and the level of AST and ALT between the groups was not significant (P>0.05). In contrast with liver pathology, the degree of fatty liver decreased with increasing dose of Huatan Mai Tong tablet. Conclusion: Huatan Mai Tong tablet has good effect on lipid lowering and is related to the dose. It has good protective effect on liver function and has good therapeutic effect on fatty liver. The mechanism of treatment may be related to the effect of lipid regulating.

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