| 石立科,王玉海,董吉荣,何建青,向定朝.超早期立体定向手术治疗高血压脑出血的疗效及对患者炎性因子和生活质量的影响[J].,2019,19(10):1962-1965 |
| 超早期立体定向手术治疗高血压脑出血的疗效及对患者炎性因子和生活质量的影响 |
| Efficacy of Ultra-early Surgery for Hypertensive Intracerebral Hemorrhage and its Effect on Inflammatory Factors and Quality of Life in Patients with Hypertensive Intracerebral Hemorrhage |
| 投稿时间：2019-01-07 修订日期：2019-01-30 |
| DOI：10.13241/j.cnki.pmb.2019.10.034 |
| 中文关键词: 超早期 立体定向手术 高血压脑出血 疗效 炎性因子 生活质量 |
| 英文关键词: Ultra-early Stereotactic surgery Hypertensive intracerebral hemorrhage Efficacy Inflammatory factors Quality of life |
| 基金项目:江苏省卫生厅科研项目（BRA2015358） |
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| 中文摘要: |
| 摘要 目的：探讨超早期立体定向手术治疗高血压脑出血（HICH）的疗效及对患者炎性因子和生活质量的影响。方法：选取2016年3月~2018年1月期间我院收治的HICH患者93例，两组均给予立体定向手术治疗，根据手术时机将患者分为早期组（n=45，发病6~24h内手术）和超早期组（n=48，发病6h内手术），比较两组疗效相关指标、炎性因子和生活质量，观察两组术后并发症发生情况。结果：超早期组病死率低于早期组，格拉斯哥昏迷评分（GOS）优良率高于早期组（P<0.05），两组术后再出血率对比差异无统计学意义（P>0.05）。两组患者术后2周白介素-6（IL-6）、超敏C反应蛋白（hs-CRP）、肿瘤坏死因子-α（TNF-α）水平均降低，且超早期组低于早期组（P<0.05）。术后3个月、术后6个月超早期组心理健康、躯体健康、社会功能、物质生活等维度评分均高于早期组（P<0.05）。超早期组术后并发症总发生率低于早期组（P<0.05）。结论：超早期立体定向手术治疗HICH，疗效显著，可有效改善炎性因子水平及患者的生活质量，同时还可减少术后并发症的发生率。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of ultra-early stereotactic surgery on hypertensive intracerebral hemorrhage (HICH) and its influence on inflammatory factors and quality of life. Methods: 93 patients with HICH who were admitted to our hospital from March 2016 to January 2018 were selected, and they were divided into early group (n=45, operation within 6-24 hours of onset) and super-early group (n=48, operation within 6 hours of onset) according to the timing of operation. Relevant indexes of curative effect, inflammatory factors and quality of life were compared between the two groups, and the occurrence of postoperative complications was observed. Results: The mortality of super-early group was lower than that of early group, and the Glasgow coma score (GOS) excellent and good rate was higher than that of early group (P<0.05). There was no significant difference in the postoperative rebleeding rate between the two groups (P>0.05). The levels of interleukin-6 (IL-6), high-sensitivity C-reactive protein (hs-CRP) and tumor necrosis factor-α (TNF-α) were decreased in the two groups at 2 weeks after operation, and those in the ultra-early group were lower than those in the early group (P<0.05). The scores of mental health, physical health, social function and material life in the ultra-early group at 3 months and 6 months after operation were higher than those in the early group (P<0.05). The total incidence of postoperative complications in the ultra-early group was lower than that in the early group (P<0.05). Conclusion: Ultra-early stereotactic surgery for HICH has remarkable curative effect, which can effectively improve inflammatory factors and quality of life, and it can also reduce the incidence of postoperative complications. |
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