| 肖 洒,胡金芳,陈思羽,吴科锋,李文德,黄 韧.microRNA-378 与肿瘤血管生成的研究进展[J].,2019,19(8):1596-1600 |
| microRNA-378 与肿瘤血管生成的研究进展 |
| Research Progress of microRNA-378 and Tumor Angiogenesis |
| 投稿时间：2018-08-10 修订日期：2018-09-06 |
| DOI：10.13241/j.cnki.pmb.2019.08.044 |
| 中文关键词: miR-378 肿瘤 血管生成 |
| 英文关键词: miR-378 Tumor Angiogenesis |
| 基金项目:国家自然科学基金项目（31772549） |
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| 中文摘要: |
| 摘要：微小RNA（MicroRNAs，miRNAs）是真核生物中一类长度约为21到23个核苷酸的非编码小分子单链 RNA。miRNA通过与靶 mRNA 3′UTR （3′-untranslated region，3′非编码区）完全或不完全结合，抑制翻译或直接诱导其降解，发挥转录后负调控作用。miRNA参与机体多种生理和病理过程，且可通过调控其靶标基因参与各种信号通路，影响血管生成。miR-378属于诸多 miRNAs中的一种。目前已知 miR-378的研究主要集中在肿瘤发生及血管生成、心血管疾病和脑缺血等病理过程，其中与肿瘤发生及血管生成相关研究居多。miR-378在不同肿瘤中的发挥的作用也不一样，在脑胶质瘤，肺癌，横纹肌肉瘤等肿瘤中发挥促癌基因的作用，在卵巢癌，胃癌，大肠癌等肿瘤中发挥抑癌基因的作用。但是，miR-378调节肿瘤血管生成的作用机制还有待于深入研究。本文主要对miR-378在四种肿瘤（脑胶质瘤、肺腺癌、卵巢癌和横纹肌肉瘤）中调控血管生成的相关性研究进展进行综述，以期为这些疾病的治疗和预防提供一种新的思路。 |
| 英文摘要: |
| ABSTRACT: MicroRNAs (miRNAs) are non-coding small-molecule single-stranded RNAs of approximately 21 to 23 nucleotides in length in eukaryotes. The miRNA inhibits translation or directly induces degradation by completely or incompletely binding to the target mRNA 3'UTR (3'-untranslated region, 3' non-coding region), and exerts a negative post-transcriptional regulation. Numerous studies have shown that miRNAs participate in a variety of physiological and pathological processes in the body, and can affect angiogenesis by regulating their target genes to participate in signaling pathways. MiR-378 is one of the families of miRNAs. At present, miR-378 is mainly studied in the pathogenesis of tumorigenesis and angiogenesis, cardiovascular disease and cerebral ischemia, and most of the studies related to tumorigenesis and angiogenesis. MiR-378 plays a different role in different tumor tissues, and plays a role as a tumor-promoting gene in glioma, lung cancer, rhabdomyosarcoma, etc., and acts as a tumor suppressor gene in tumors such as ovarian cancer, gastric cancer, colorectal cancer. However, the mechanism by which miR-378 regulates tumor angiogenesis remains to be further studied. This study mainly introduces the progress of miR-378 in the regulation of angiogenesis in four tumors (glioma, lung adenocarcinoma, ovarian cancer and rhabdomyosarcoma), providing a new idea for the treatment and prevention of these diseases. |
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