| 贾 静,师二姣,郭利丽,冯 玲,王少帅.内皮克隆形成细胞的研究进展和应用前景[J].,2019,19(8):1583-1586 |
| 内皮克隆形成细胞的研究进展和应用前景 |
| Current Progress and Application Prospect of Endothelial Colony-forming Cells |
| 投稿时间：2018-10-28 修订日期：2018-11-23 |
| DOI：10.13241/j.cnki.pmb.2019.08.041 |
| 中文关键词: 内皮克隆形成细胞 血管再生 组织工程 肿瘤 |
| 英文关键词: Endothelial colony-forming cells Vascularization Tissue engineering Tumor |
| 基金项目:国家重点研究发展计划项目(2016YFC1000405；2018YFC1002900) |
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| 摘要点击次数: 649 |
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| 中文摘要: |
| 摘要：内皮克隆形成细胞（endothelial colony-forming cells, ECFCs）是内皮祖细胞（endothelial progenitor cells, EPCs）的一种亚型，具有高度增殖、克隆形成和裸鼠体内血管形成的能力，在维持血管稳态方面发挥着重要作用。ECFCs的来源很广，包括外周血、脐血、骨髓、血管壁，以及人诱导的多功能干细胞(human-induced pluripotent stem cells , hiPSCs)，其中研究较为深入的是外周血ECFCs（PB-ECFCs）和脐血ECFCs（CB-ECFCs）。在此，我们将简要介绍ECFCs功能障碍与疾病的相关性，总结ECFCs在缺血损伤、组织工程以及肿瘤治疗领域的基础研究进展和应用前景，最后对小鼠体内研究的局限性以及细胞体外培养条件改良等问题进行探讨。 |
| 英文摘要: |
| ABSTRACT: Endothelial colony-forming cells (ECFCs), a subtype of endothelial progenitor cells(EPCs), play an important role in maintaining vascular homeostasis. ECFCs are characterized by robust proliferative potential, colony forming ability and ability to form intrinsic in vivo vessels upon transplantation into immunodeficient mice. They have been successfully isolated from the peripheral blood（PB-ECFCs）, umbilical cord blood（CB-ECFCs）, bone marrow and wall of numerous arterial and venous vessels, and derived from human-induced pluripotent stem cells(hiPSCs). Here we will briefly describe the involvement of ECFCs in various diseases, summarize the current progress and application prospect of CB-ECFCs in ischemia repair, tissue engineering and tumor therapy, and highlight the limitations of in vivo studies in mice and the improvement of cell culture conditions in vitro. |
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