| 蔡珠虹,赵 静,刘天佳,王凌霄,蒋 栋.慢性心力衰竭患者N端脑钠肽前体、脑钠肽与患者心脏超声参数及炎症因子的关系[J].,2019,19(8):1459-1462 |
| 慢性心力衰竭患者N端脑钠肽前体、脑钠肽与患者心脏超声参数及炎症因子的关系 |
| Relationship between N Terminal Pro-brain Natriuretic Peptide, Brain Natriuretic Peptide, Cardiac Ultrasound Parameters and Inflammatory Factors in Patients with Chronic Heart Failure |
| 投稿时间：2018-07-04 修订日期：2018-07-27 |
| DOI：10.13241/j.cnki.pmb.2019.08.013 |
| 中文关键词: 慢性心力衰竭 N端脑钠肽前体 脑钠肽 心脏超声参数 |
| 英文关键词: Chronic heart failure N pro brain natriuretic peptide Brain natriuretic peptide Cardiac function parameters |
| 基金项目:上海市科学技术委员会基金项目（13411426300） |
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| 中文摘要: |
| 摘要 目的：探讨慢性心力衰竭（CHF）患者N端脑钠肽前体（NT-proBNP）、脑钠肽（BNP）与患者心脏超声参数及炎症因子的关系。方法：选取2015年3月~2018年2月期间我院收治的CHF患者135例为研究组。根据纽约心脏病学协会（NYHA）心功能分级将研究组分为I级组26例，II级组34例，III级组42例，IV级组33例。另选取同期于我院体检的健康志愿者30例为对照组。检测并比较对照组与研究组、不同NYHA心功能分级的血清标志物、炎症因子、心功能超声参数，采用Pearson相关性分析NT-proBNP、BNP与炎症因子、心功能超声参数的相关性。结果：研究组血清BNP、NT-proBNP、白介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）、超敏C反应蛋白（hs-CRP）水平及左心室舒张末期内径（LVEDD）、左心室收缩末期内径（LVESD）均显著高于对照组，左心室射血分数（LVEF）则低于对照组（P<0.05)。BNP、NT-proBNP、IL-6、TNF-α、hs-CRP水平及LVEDD、LVESD随心功能分级的升高而升高，LVEF随心功能分级的升高而降低（P<0.05）。经Pearson相关性分析显示，CHF患者BNP、NT-proBNP与IL-6、TNF-α、hs-CRP、LVEDD、LVESD呈正相关，而与LVEF呈负相关（P<0.05）。结论：血清NT-proBNP、BNP与CHF患者的心脏超声参数及炎症因子密切相关，可考虑将其作为临床诊断CHF的生物学指标。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between N- terminal pro brain natriuretic peptide (NT-proBNP) and brain natriuretic peptide (BNP) and cardiac ultrasound parameters and inflammatory factors in patients with chronic heart failure (CHF). Methods: 135 cases of CHF who were treated in our hospital from March 2015 to February 2018 were selected as the study group. According to the cardiac function classification of New York cardiology Association (NYHA), the study group was divided into I group with 26 cases, II class with 34 cases, III class with 42 cases, IV class with 33 cases.Another 30 healthy volunteers who received physical examination in the same period were selected as control group. The serum markers,inflammatory factors and cardiac function parameters of the control group and the study group, the NYHA group were compared.Pearson correlation analysis was used to analyze the correlation between NT-proBNP and BNP and inflammatory factors and echocardiography parameters. Results: The serum BNP, NT-proBNP, interleukin -6 (IL-6), tumor necrosis factor-α (TNF-α), hypersensitive C reactive protein (hs-CRP), left ventricular end diastolic diameter (LVEDD) and left ventricular end systolic diameter (LVESD) were significantly higher than those in the control group, the left ventricular ejection fraction (LVEF) was lower than that of the control group (P<0.05). The level of BNP, NT-proBNP, IL-6, TNF-α, hs-CRP and LVEDD and LVESD increased with the increase of cardiac function classification, and LVEF decreased with the increase of following function classification(P<0.05). Pearson correlation analysis showed that BNP and NT-proBNP in CHF patients were positivelycorrelated with IL-6,TNF-α, hs-CRP, LVEDD and LVESD, but negatively correlated with LVEF (P<0.05). Conclusion: Serum NT-proBNP and BNP are closely related to CHF echocardiographic parameters and inflammatory factors. It may be considered as a biological marker for clinical diagnosis of CHF. |
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