王彩霞,李梦娇,刘云章,李 筠,卢 玲,周建峰,荣小至.硫酸软骨素在癌症治疗领域的研究进展[J].,2019,19(7):1379-1382 |
硫酸软骨素在癌症治疗领域的研究进展 |
Research Progress of Chondroitin Sulfate in Cancer Therapy |
投稿时间:2018-06-08 修订日期:2018-06-30 |
DOI:10.13241/j.cnki.pmb.2019.07.040 |
中文关键词: 硫酸软骨素 癌症治疗 肿瘤标志物 |
英文关键词: Chondroitin sulfate Cancer therapy Tumor markers |
基金项目:国家自然科学基金项目(31572261, 31601863);国家基金委-山东省联合基金项目(U1406402) |
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中文摘要: |
摘要:硫酸软骨素是一种硫酸化的糖胺聚糖,其在恶性肿瘤组织中的含量、结构、硫酸化位点等与正常组织存在显著差异,在癌症的迁移,侵袭,血管生成过程中发挥重要调控作用,在癌症的临床研究中具有很大潜力。该文对硫酸软骨素的生物合成进行归类分析,对近几年硫酸软骨素与肿瘤入侵和转移的相关临床研究以及分子机制研究做出综述,以期为开发硫酸软骨素潜在的临床价值和肿瘤治疗靶点研究提供理论依据,为恶性肿瘤的早期诊断和预后评估提供思路。 |
英文摘要: |
ABSTRACT: Chondroitin sulfate is a sulfated glycosaminoglycan. The content, structure and sulfur acidification site of Chondroitin sulfate in malignant tumor are significantly differ from those in normal tissue. It plays important roles in the migration, invasion, and an- giogenesis of cancer and has great potential in the clinical cancer research. In this paper, the biosynthesis of chondroitin sulfate was in- ductive analysis. Progress of clinical studies and molecular mechanism of tumor invasion and metastasis regulated by chondroitin sulfate in recent years was reviewed to provide a theoretical basis for developing the potential clinical value of chondroitin sulfate and the tumor treatment targets as well as to provide an idea for early diagnosis and prognosis of malignant tumors. |
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