| 卜 桐,崔乐乐,刘兆基,张涵旭,史 雨,李爱梅,考文萍,翟爱霞.单克隆抗体在抗病毒感染中的研究进展[J].,2019,19(6):1188-1192 |
| 单克隆抗体在抗病毒感染中的研究进展 |
| Research Progress of Monoclonal Antibody in Viral Infection |
| 投稿时间：2018-10-08 修订日期：2018-10-31 |
| DOI：10.13241/j.cnki.pmb.2019.06.042 |
| 中文关键词: 单克隆抗体 抗病毒 作用机制 |
| 英文关键词: Monoclonal antibody Antivirus Mechanism of action |
| 基金项目:国家自然科学基金项目（81501737）；黑龙江省自然科学基金项目（H2015009）；黑龙江省教育厅科学技术研究项目（12541365）；黑龙江省博士后科研启动基金项目（LBH-Q14120） |
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| 中文摘要: |
| 摘要：单克隆抗体（monoclonal antibody, mAb），指同一种抗原决定簇的细胞克隆所产生的均一性抗体。mAb已成功应用以诊疗各种疾病，尤其是癌症和免疫性疾病。近些年来，mAb逐渐用于治疗病毒性疾病，针对急性和慢性病毒感染研发的抗病毒mAb数量逐渐增长。mAb的组合疗法可同时靶向病毒多个表位，从而克服病毒免疫逃逸的问题，多价mAb的设计开发能够更加有效的作用于病毒。本文比较了不同mAb制备方法的优缺点，总结了mAb近期在抗病毒感染领域的研究进展，并讨论了mAb作为治疗病毒性疾病药物的前景。 |
| 英文摘要: |
| ABSTRACT: Monoclonal antibody refers to the homogenous antibody produced by the cell clone of the same antigen determinant. MAb has been successfully used in the treatment of various diseases, especially cancer and immune diseases. However, in recent years, monoclonal antibody has gradually been used to treat viral infections. The number of anti-viral monoclonal antibody developed for acute and chronic viruses has gradually increased. The combination therapy of mAb can target multiple epitopes of virus at the same time, so as to overcome the problem of virus immune escape. The design and development of multivalent monoclonal antibody can act on virus more effectively. In this paper, the advantages and disadvantages of different preparation methods of mAb were compared, and the recent research progress of mAb in the field of antiviral was summarized. The prospect of mAb as a drug for treating viral diseases was discussed. |
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