| 刘亚茹,汪 涛,马 羚,王申森,黄 华,黄映辉.表观遗传学与肺癌[J].,2019,19(6):1176-1179 |
| 表观遗传学与肺癌 |
| Epigenetics and Lung Cancer |
| 投稿时间：2018-04-30 修订日期：2018-05-26 |
| DOI：10.13241/j.cnki.pmb.2019.06.039 |
| 中文关键词: DNA甲基化 组蛋白修饰 肺癌 miRNA |
| 英文关键词: DNA methylation Histone modification Lung cancer miRNA |
| 基金项目:北京市科委重点项目（K2015311201501） |
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| 中文摘要: |
| 摘要：表观遗传是在指不影响遗传序列的情况下影响型状表达的方法。除了经典遗传方面，如点突变、颠换、插入与肺癌的发生有关，近年来研究显示表观遗传学对肺癌的发生也起到了重要的作用。本文主要从表观遗传学角度，简述了DNA甲基化、组蛋白修饰、非编码RNA尤其是miRNA与肺癌的关系，甲基化主要是通过抑制原癌基因，促进抑癌基因表达导致肺癌，组蛋白修饰会促进抑癌基因的表达，非编码RNA可以作为肺癌诊断的生物标记物，为肺癌的早期诊断提供依据。 |
| 英文摘要: |
| ABSTRACT: Epigenetics refers to affecting the expression of a pattern without affecting the genetic sequence. In addition to the classical genetic, such as point mutations, transversion, insertion, in recent years found that epigenetics also played an important role in lung cancer. There is a brief description between the DNA methylation, histone modification, non-coding RNA, especially miRNA and lung cancer, methylation leading to lung cancer mainly through the inhibition of oncogene, promote tumor suppressor gene expression, histone modification can promote the expression of tumor suppressor gene, non-coding RNA can be used as a biomarker for the diagnosis of lung cancer, providing a basis for the early diagnosis of lung cancer. |
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