| 王富林,陈 旭,从芳芳,舒 键,唐光才.多层CT灌注成像参数与胃癌患者病理分化程度和血清CEA、AFP、CA72-4的关系研究[J].,2019,19(6):1122-1125 |
| 多层CT灌注成像参数与胃癌患者病理分化程度和血清CEA、AFP、CA72-4的关系研究 |
| Relationship between Multi-slice CT Perfusion Imaging Parameters and Pathological Differentiation of Gastric Cancer Patients and Serum CEA, AFP and CA72-4 |
| 投稿时间：2018-09-26 修订日期：2018-10-21 |
| DOI：10.13241/j.cnki.pmb.2019.06.026 |
| 中文关键词: 多层CT灌注成像 胃癌 分化程度 肿瘤标志物 相关性 |
| 英文关键词: Multi-slice CT perfusion imaging Gastric cancer Degree of differentiation Tumor markers Correlation |
| 基金项目:四川省卫生和计划生育委员会科研项目（1500196） |
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| 中文摘要: |
| 摘要 目的：探讨多层CT灌注成像参数与胃癌患者病理分化程度和血清癌胚抗原（CEA）、甲胎蛋白（AFP）、糖抗原72-4（CA72-4）的关系。方法：选取2016年5月到2018年5月期间在我院接受治疗的胃癌患者60例作为胃癌组，根据患者肿瘤细胞不同病理分化程度将患者分成中高分化组（34例）和低分化组（26例），另选取同期于我院进行健康检查的60例健康志愿者作为对照组。比较不同病理分化程度的胃癌患者多层CT灌注成像参数[血流量（BF）、达峰时间（TTP）、Patlak血容量（PBV）、Patlak表面通透性（PPS）]，比较胃癌组和对照组血清CEA、AFP、CA72-4水平，分析胃癌患者多层CT灌注成像参数与血清肿瘤标志物的相关性。结果：胃癌组血清CEA、AFP、CA72-4水平明显高于对照组，差异有统计学意义（P<0.05）。中高分化组PBV、PPS均明显低于低分化组，TTP明显高于低分化组，差异有统计学意义（P<0.05），中高分化组和低分化组的BF比较差异无统计学意义（P>0.05）。经Pearson法分析显示，胃癌患者的BF、TTP、PBV与CEA、AFP、CA72-4无明显的相关性（P>0.05），PPS与CEA、AFP、CA72-4呈正相关（P<0.05）。结论：胃癌患者的多层CT灌注成像参数与患者的病理分化程度有关，且部分参数还与血清肿瘤标志物CEA、AFP、CA72-4呈正相关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the relationship between multi-slice CT perfusion imaging parameters and pathological differentiation of gastric cancer patients and serum carcinoembryonic antigen (CEA), alpha fetoprotein (AFP) and carbohydrate antigen 72-4 (CA72-4). Methods: 60 patients with gastric cancer who were treated in our hospital from May 2016 to May 2018 were selected as the gastric cancer group. According to the different differentiation degree of tumor cells, they were divided into moderately well-differentiated group (34 cases) and poorly differentiated group (26 cases). 60 healthy volunteers who were examined in our hospital during the same period were selected as the control group. The multi-slice CT perfusion imaging parameters of blood flow (BF), peak time (TTP), Patlak blood volume (PBV), and Patlak surface permeability (PPS) were compared between gastric cancer patients with different pathological differentiation. The serum CEA, AFP, and CA72-4 levels in gastric cancer group and control group were compared, the correlation between multi-slice CT perfusion imaging parameters and serum tumor markers in patients with gastric cancer were analyzed. Results: The levels of serum CEA, AFP and CA72-4 in the gastric cancer group were significantly higher than those in the control group, and the differences were statistically significant (P<0.05). The PBV and PPS of the moderately well-differentiated group were significantly lower than those of the poorly differentiated group, and the TTP was significantly higher than that of the poorly differentiated group, the differences were statistically significant (P<0.05). There was no significant difference in BF between moderately well-differentiated group and poorly differentiated groups (P>0.05). Pearson analysis showed that there were no significant correlation between BF, TTP, PBV and CEA, AFP,CA72-4 in gastric cancer patients (P>0.05). PPS was positively correlated with CEA, AFP and CA72-4 (P<0.05). Conclusion: The multi-slice CT perfusion imaging parameters of gastric cancer patients are related to the pathological differentiation of patients, and some parameters are positively correlated with serum tumor markers CEA, AFP and CA72-4. |
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