| 赵继荣,王国慧,赵 宁,慕向前,朱 宝.经皮激光汽化术联合杜仲腰痛丸治疗腰椎间盘突出症的效果观察[J].,2019,19(6):1095-1098 |
| 经皮激光汽化术联合杜仲腰痛丸治疗腰椎间盘突出症的效果观察 |
| Observation on the Effect of Percutaneous Laser Vaporization Combined with Duzhongyaotong Pill in the Treatment of Lumbar Disc Herniation |
| 投稿时间：2018-09-05 修订日期：2018-09-30 |
| DOI：10.13241/j.cnki.pmb.2019.06.020 |
| 中文关键词: 经皮激光汽化术 杜仲腰痛丸 腰椎间盘突出症 临床疗效 |
| 英文关键词: Percutaneous laser vaporization Duzhongyaotong pill Lumbar intervertebral disc Clinical efficacy |
| 基金项目:国家自然科学基金项目(81760877) |
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| 中文摘要: |
| 摘要 目的：研究经皮激光汽化术联合杜仲腰痛丸治疗腰椎间盘突出症的临床效果。方法：选择2016年4月～2018年4月我院脊柱骨科收治的106例腰椎间盘突出症患者，随机分为两组。对照组单独采用经皮激光汽化术治疗，观察组联合口服杜仲腰痛丸治疗，每次8粒，每天3次。比较两组的治疗有效率，治疗前后的VAS评分、JOA评分，血清白介素-1β(IL-1β)、肿瘤坏死因子-α(TNF-α)水平的改变情况。结果：治疗后，观察组的治疗有效率为88.68 %(47/53)，明显高于对照组[73.58 %(39/53)](P<0.05)。两组治疗后的VAS评分值均较治疗前明显降低(P<0.05)，JOA评分值均较对照组明显升高(P<0.05)，且观察组VAS评分值明显低于对照组，JOA评分值显著高于对照组(P<0.05)。两组治疗后的血清IL-1β、TNF-α水平均较治疗前明显降低(P<0.05)，且观察组血清IL-1β、TNF-α水平明显低于对照组(P<0.05)。两组均未发生神经损伤和无椎间盘炎等并发症。结论：经皮激光汽化术联合杜仲腰痛丸治疗腰椎间盘突出症的临床效果明显优于单独采用经皮激光汽化术治疗，其可以显著改善患者的生活质量，降低疼痛程度，其作用机制可能与有降低患者血清炎症介质IL-1β、TNF-α的表达有关。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical effect of percutaneous laser vaporization combined with duzhongyaotong pill in the treatment of lumbar disc herniation. Methods: 106 cases of patients with lumbar disc herniation who were treated in our hospital from April 2016 to April 2018 were selected and randomly divided into two groups. The control group was treated with percutaneous laser vaporization alone, and the observation group was treated with duzhongyaotong pill orally, 8 capsules each time, 3 times a day. The therapeutic efficacy, changes of VAS score, JOA score, serum interleukin-1β(IL-1β) and tumor necrosis factor-α(TNF-α) levels before and after treatment were compared between the two groups. Results: After treatment, the effective rate of observation group was 88.68% (47/53), which was significantly higher than that of control group [73.58% (39/53)] (P<0.05). After treatment, the VAS scores of both groups were significantly lower than those before treatment (P<0.05), while the JOA scores were significantly higher than those before treatment (P<0.05), and the VAS scores of observation group were significantly lower than those of the control group, and the JOA scores were significantly higher than those of the control group (P<0.05). The serum levels of IL-1β and TNF-α in both groups were significantly lower than those before treatment (P<0.05), and the serum levels of IL-1β and TNF-α in the observation group were significantly lower than those in the control group (P<0.05). No neurological injury or intervertebral disc inflammation occurred in the two groups. Conclusion: The clinical effect of percutaneous laser vaporization combined with duzhongyaotong pill in the treatment of lumbar intervertebral disc herniation was better than that of percutaneous laser vaporization alone, which can significantly improve the quality of life of patients and reduce the degree of pain, and its mechanism may be related to the reduction of serum inflammatory mediators IL-1β and TNF-α expression. |
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