| 程生博,帖金鑫,李 萌,马 林.烟碱抗阿尔茨海默病作用研究进展[J].,2019,19(5):975-978 |
| 烟碱抗阿尔茨海默病作用研究进展 |
| Research Progress on the Effect of Nicotine against Alzheimer's Disease |
| 投稿时间：2018-03-27 修订日期：2018-04-23 |
| DOI：10.13241/j.cnki.pmb.2019.05.040 |
| 中文关键词: 烟碱 阿尔茨海默病 氧化应激 神经保护 |
| 英文关键词: Nicotine Alzheimer's disease Oxidative stress Neuroprotective |
| 基金项目:国家自然科学基金项目（20976169） |
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| 中文摘要: |
| 摘要：烟碱是存在于烟草植物中的主要生物碱，是代表性的乙酰胆碱激动剂类药物，对中枢神经系统以及乙酰胆碱受体均有一定作用。文章针对烟碱对烟碱抗阿尔茨海默病的作用机制进行综述，并对阿尔茨海默病的治疗作用展开讨论。如：调节胆碱能、减轻氧化应激、抑制Aβ生成及聚合以及神经保护作用。为抗阿尔茨海默病的药物筛选提供了一条极具潜力的研发途径。 |
| 英文摘要: |
| ABSTRACT: Nicotine, the main alkaloid found in tobacco plants, which is a representative agonist of acetylcholine, has some effect on the central nervous system and acetylcholine receptors. In this article, the mechanism of nicotine resistance to Alzheimer's disease was summarized and the therapeutic effect of nicotine on Alzheimer's disease was also discussed, such as regulating cholinergic, reducing ox- idative stress, inhibiting Aβ production and aggregation, and neuroprotective effects. It provides a promising approach to drug screening for Alzheimer's disease. |
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