| 刘 璐,赵艳滨,李 欣,张明辉,王 艳.miR-206在肺癌中的作用及机制研究进展[J].,2019,19(4):785-788 |
| miR-206在肺癌中的作用及机制研究进展 |
| The Research Progress of the Role and Mechanism of miR-206 in Lung Cancer |
| 投稿时间：2018-04-23 修订日期：2018-05-18 |
| DOI：10.13241/j.cnki.pmb.2019.04.040 |
| 中文关键词: miR-206 肺癌 增殖抑制 研究进展 |
| 英文关键词: MiR-206 Lung cancer Proliferation inhibition Research progress |
| 基金项目:国家自然科学基金面上项目（81673024）；哈尔滨市科技创新人才优秀学科带头人项目（2016RAXYJ076）；黑龙江省省属高等学校基本科研业务费基础研究项目（2017LCZX95）；黑龙江省卫生厅科研课题（2016-102） |
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| 中文摘要: |
| 摘要：肺癌是现今全世界死亡率和发病率最高的恶性肿瘤，严重危及人类健康，其中超过85%的患者为非小细胞肺癌，5年预计生存期不超过16%。微小RNA（microRNA，miRNA）是一类在基因组转录出来后直接在RNA水平上行使生物学功能的非编码RNA，大小约20～25个核苷酸组成，广泛存在于真核生物中。miRNA可通过对癌基因或抑癌基因进行转录后调控而发挥类似于癌基因或抑癌基因的作用。MicroRNA-206（miR-206）定位于人类第6号染色体上，最早从骨骼肌中发现，它参与人体中一系列的生物学过程例如细胞增殖，组织器官的生长及肿瘤的发生等。最近大量研究显示miR-206在肿瘤细胞中表达失调，在肿瘤的生长、增殖、凋亡及侵袭、转移、耐药中发挥重要作用。本文就miR-206在肺癌中的作用及其机制的研究进展作一综述。 |
| 英文摘要: |
| ABSTRACT: Lung cancer is a malignant tumor with the highest mortality and morbidity in the world today, which seriously endan- gers human health. Over 85% of these patients are non-small cell lung cancer, and the survival period is not more than 16% in 5 years. Small RNA (miRNA, miRNA) is a kind of transcription in genome out directly after the exercise of biological function at the RNA level of non-coding RNA, size is about 20~25 nucleotides, widely exists in eukaryotic organisms. MiRNA may play a role in the regulation of oncogenes or tumor suppressor genes by post-transcriptional regulation of oncogenes or tumor suppressor genes. MicroRNA-206 (miR-206) in human chromosome 6, the earliest found in skeletal muscle, its participation in the body of a series of biological processes such as cell proliferation, the growth of tissues and organs and the occurrence of tumors, etc. Recently, a large number of studies have shown that mir-206 is misrepresented in tumor cells and plays an important role in tumor growth, proliferation, apoptosis, invasion, metastasis, and drug resistance. This article reviews the research progress of mir-206 in lung cancer and its mechanism. |
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