| 王婷婷,徐衍华,郭玉倩,李智娟,成志锋.痛风的相关研究[J].,2019,19(2):389-392 |
| 痛风的相关研究 |
| Gout Related Research |
| 投稿时间：2018-02-06 修订日期：2018-02-28 |
| DOI：10.13241/j.cnki.pmb.2019.02.041 |
| 中文关键词: 痛风 流行病学 饮食 诊断 展望 |
| 英文关键词: Gout Epidemiology Diet Diagnosis Prospect |
| 基金项目: |
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| 摘要点击次数: 891 |
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| 中文摘要: |
| 摘要：痛风是一种由高尿酸血症引起的关节炎类型。研究其流行病学，使临床对高尿酸血症及痛风性关节炎的病理生理学有了新的见解。研究表明，遗传倾向的作用越来越明显。痛风的临床表现分为无症状高尿酸血症，急性痛风性关节炎，发作间期和慢性痛风性关节炎。痛风的诊断基于实验室和放射学特征，其中偏振光显微镜发现滑液中针状或杆状的单钠尿酸盐晶体是诊断的金标准。其成像方法主要有常规放射成像、超声检查、双能CT。其中超声和双能CT应用的进步使该领域的诊断、分期、随访和临床研究有了显著的提高。深入了解痛风的发病机制，不断优化诊断方式，有助于提高痛风的临床诊疗水平。痛风的管理一直是医学史上对医学技能的挑战，当前需要不断深入了解痛风的发病机制，不断优化诊断方式，以寻求不同寻常的治疗方案。在秋水仙碱、泼尼松、别嘌醇、非布司他、雷西纳德等药物的临床应用取得不错效果的同时，存在的一些不良反应值得重视。随着精准医疗时代的到来，相信痛风的个体化诊疗有着更加乐观的未来。 |
| 英文摘要: |
| ABSTRACT: Gout is a type of arthritis caused by hyperuricemia. Studying its epidemiology has new insights into the pathophysiol- ogy of hyperuricemia and gouty arthritis. The role of genetic predisposition is more and more obvious. The clinical manifestations of gout are divided into asymptomatic hyperuricemia, acute gouty arthritis, seizures and chronic gouty arthritis. The diagnosis of gout is based on laboratory and radiological features, of which polarizing microscopy has found that needle-shaped or rod-shaped monosodium urate crys- tals in synovial fluid are the gold standard for diagnosis. Imaging methods are conventional radiological imaging, ultrasound, dual-energy CT. Advances in the use of ultrasound and dual-energy CT have led to significant improvements in the field of diagnosis, staging, fol- low-up and clinical studies. In-depth understanding of the pathogenesis of gout, continuous optimization of diagnostic methods, and thus improve the clinical diagnosis and treatment of gout. Management of gout has always been a medical medical challenge in medical histo- ry. Currently, there is a need to continuously understand the pathogenesis of gout and to constantly optimize diagnostic methods to seek for unusual treatment options. In the colchicine, prednisone, allopurinol, febuxostat, lesinurad and other drugs to achieve good clinical re- sults at the same time, there are some adverse reactions worthy of attention. With the advent of the era of precision medicine, individual- ized treatment of gout has a more optimistic future. |
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