| 郭雪珂,周 林,谢 冰,刘佳佳,方 杰,凌秀凤.长链非编码RNA及其与疾病相关性的研究进展*[J].,2019,19(1):185-188 |
| 长链非编码RNA及其与疾病相关性的研究进展* |
| The Development of Long non-coding RNA and its Association with Disease* |
| 投稿时间：2018-02-24 修订日期：2018-03-18 |
| DOI：10.13241/j.cnki.pmb.2019.01.040 |
| 中文关键词: 长链非编码RNA 结构特征 作用机制 生物学功能 |
| 英文关键词: Long non-coding RNA Architectural feature Mechanism Biological function |
| 基金项目:国家自然科学基金青年基金项目(31401225)；镇江市卫生科技重点项目(SHW2016001) |
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| 中文摘要: |
| 摘要：人类基因组中，用于蛋白质编码的核酸序列约占1.5 %，另外98.5 %的非蛋白编码基因被视为“噪音”序列，并未引起人们的注意。随着测序技术的发展，人们发现大部分的基因被转录成RNA，其中多数为长度大于200nt且不编码蛋白质的长链非编码RNA（Long non-coding RNA, lncRNA），其作用机制包括支架分子、引导分子等，广泛参与细胞发育、增殖及迁移过程，且其水平的改变又与肿瘤、代谢性疾病等相关。本文主要对lncRNA的分类、作用机制及涉及的疾病等进行综述，为进一步研究lncRNA的功能机制奠定基础。 |
| 英文摘要: |
| ABSTRACT: In the human genome, only 1.5 % of them are used for protein coding, while the another 98.5 % are considered to be “noise” sequence. With the development of sequencing technology, most of the transcriptional RNAs are long non-coding RNA (lncRNA) that were longer than 200 nucleotides and did not encode proteins. The functional mechanism include Molecular scaffolds, Guides and so on, widely involved in cell growth, proliferation and migration process, and the level of change is associated with tumor and metabolic diseases. This review summarizes the classification, the functional mechanism and the diseases involved of lncRNA, providing the foundation for researchers in future study in lncRNA. |
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