| 杨峰霞,叶家卫,房春晓,徐 翼,谭丽梅.熊去氧胆酸对婴儿肝炎综合征患儿血清炎症因子和肝功能的影响*[J].,2019,19(1):104-107 |
| 熊去氧胆酸对婴儿肝炎综合征患儿血清炎症因子和肝功能的影响* |
| Effects of Ursodeoxycholic Acid on Serum Inflammatory Factors and Liver Function in Infants with Infantile Hepatitis Syndrome* |
| 投稿时间：2018-04-27 修订日期：2018-05-23 |
| DOI：10.13241/j.cnki.pmb.2019.01.022 |
| 中文关键词: 熊去氧胆酸 婴儿肝炎综合征 患儿 炎症因子 肝功能 疗效 |
| 英文关键词: Ursodeoxycholic acid Infantile hepatitis syndrome Infants Inflammatory factors Liver function Curative effect |
| 基金项目:广东省人口和计划生育委员会科研项目（20132641） |
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| 中文摘要: |
| 摘要 目的：探讨熊去氧胆酸对婴儿肝炎综合征患儿血清炎症因子和肝功能的影响。方法：选取我院自2013年5月-2015年5月收治的婴儿肝炎综合征患儿91例，随机分为对照组（n=47）和观察组（n=44），对照组患儿给予常规护肝、利胆等治疗，观察组患儿在对照组的基础上给予熊去氧胆酸治疗，两组均治疗3周。比较两组患儿治疗前后的血清炎症因子及肝功能指标水平，观察两组患儿用药后的临床治疗效果及不良反应发生情况。结果：治疗后，所有患儿的血清肿瘤坏死因子-α（TNF-α）、白细胞介素-6（IL-6）、总胆红素（TBil）、直接胆红素（DBil）、丙氨酸转氨酶（ALT）、谷氨酰转肽酶（GGT）、总胆汁酸（TBA）水平均低于治疗前，且观察组低于对照组（P<0.05）。观察组患儿治疗后总有效率高于对照组（P<0.05）。两组患儿总不良反应发生率比较差异无统计学意义（P>0.05）。结论：熊去氧胆酸可以减轻婴儿肝炎综合征患儿的炎症反应，改善其肝功能，疗效显著且安全性好。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of ursodeoxycholic acid on serum inflammatory factors and liver function in infants with infantile hepatitis syndrome. Methods: 91 infants with infantile hepatitis syndrome who were treated in our hospital from May 2013 to May 2015 were selected, and they were randomly divided into control group (n=47) and observation group (n=44), the control group were given routine liver protection and gallbladder treatment, the observation group were given ursodeoxycholic acid on the basis of the control group, and the two groups were treated for 3 weeks. The levels of serum inflammatory factors and liver function indexes were compared between the two groups before and after treatment. The clinical effects and adverse reactions of two groups after medication were observed. Results: After treatment, the levels of serum tumor necrosis factor-α (TNF-α), interleukin -6 (IL-6), total bilirubin (TBil), direct bilirubin (DBil), alanine transaminase (ALT), glutamyl transaminopeptidase (GGT) and total bile acid (TBA) in all infants were lower than those before treatment, and the observation group was lower than the control group (P<0.05). The total effective rate of the observation group after treatment was higher than that of the control group (P<0.05). There was no significant difference in the incidence of the total adverse reactions between the two groups (P>0.05).Conclusion: Ursodeoxycholic acid can reduce the inflammatory reaction and improve the liver function of infants with hepatitis syndrome, the curative effect is remarkable, and the safety is good. |
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