| 林 刚,杨 晴,林 周,薛育政,余利华.加贝酯联合奥曲肽对急性胰腺炎患者胃肠功能、免疫功能及炎性因子水平的影响[J].,2018,(24):4727-4730 |
| 加贝酯联合奥曲肽对急性胰腺炎患者胃肠功能、免疫功能及炎性因子水平的影响 |
| Effect of Gabexate Combined with Octreotide on Gastrointestinal Function,Immune Function and Inflammatory Factors in Patients with Acute Pancreatitis |
| 投稿时间：2018-08-05 修订日期：2018-08-28 |
| DOI：10.13241/j.cnki.pmb.2018.24.028 |
| 中文关键词: 加贝酯 奥曲肽 急性胰腺炎 胃肠功能 免疫功能 炎症因子 |
| 英文关键词: Gabexate Octreotide Acute pancreatitis Gastrointestinal function Immune function Inflammatory factors |
| 基金项目:江苏省自然科学基金青年科技人才专项（BK20141371） |
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| 中文摘要: |
| 摘要 目的：探讨加贝酯联合奥曲肽对急性胰腺炎（AP）患者胃肠功能、血清炎性因子及免疫功能的影响。方法：选取2014年1月到2018年6月在我院接受治疗的AP患者100例，采用随机数字表法将所有患者分为对照组和观察组各50例。对照组给予注射用醋酸奥曲肽治疗，观察组在对照组的基础上给予注射用甲磺酸加贝酯治疗。对比两组患者治疗后临床疗效、胃肠功能恢复情况、血清炎性因子水平及免疫球蛋白lgG、lgM、lgA的变化情况。结果：治疗后观察组总有效率为83.24%，高于对照组的67.03%（P<0.05）。治疗后观察组排气恢复时间、排便恢复时间、肠鸣音消失时间、腹胀缓解时间、腹痛缓解时间均显著短于对照组（P<0.05）。治疗后两组肿瘤坏死因子-α（TNF-α）、C反应蛋白（CRP）、白细胞介素-6（IL-6)及白细胞介素-8（IL-8）水平较治疗前均明显下降（P<0.05），且治疗后观察组的TNF-α、CRP、IL-6及IL-8水平低于对照组（P<0.05）。治疗后两组的lgG、lgM、lgA水平均较治疗前均明显升高（P<0.05），治疗后观察组的lgG、lgM水平高于对照组（P<0.05）。结论：加贝酯联合奥曲肽治疗AP不仅能够有效抑制患者的炎症反应，改善其免疫功能，还能够促进患者胃肠功能恢复，提高临床疗效。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of gabexate combined with octreotide on gastrointestinal function, serum inflam- matory factors and immune function in patients with acute pancreatitis (AP). Methods: 100 cases of AP patients treated in our hospital from January 2014 to June 2018 were selected. All patients were divided into control group and observation group by random number table method, with 50 cases in each group. The control group was given octreotide acetate for injection, while the observation group was given gabexate mesylate for injection on the basis of the control group. The clinical efficacy,gastrointestinal function recovery, serum in- flammatory factors and the changes of immunoglobulin lgG, lgM and lgA were compared between the two groups. Results: After treat- ment, the total effective rate of the observation group was 83.24%, which was higher than 67.03% of the control group(P<0.05). After treatment, the recovery time of exhaust, recovery time of defecation, disappearing time of bowel sound, relieving time of abdominal dis- tention, and relieving time of abdominal pain were significantly shorter than those in the control group (P<0.05). After treatment, the levels of tumor necrosis factor-α (TNF-α), C reactive protein (CRP), interleukin-6 (IL-6) and interleukin-8 (IL-8) in the two groups were sig- nificantly lower than before treatment(P<0.05), and the levels of TNF-α, CRP, IL-6 and IL-8 in the observation group were lower than those of the control group after treatment. After treatment, the levels of lgG, lgM and lgA in both groups were significantly higher than before treatment(P<0.05). After treatment, the levels of lgG and lgM in observation group were higher than those of the control group (P<0.05). Conclusion: Gabexate combined with octreotide in the treatment of AP can not only effectively inhibit the inflammatory re- sponse of the patients,improve the immune function, but also promote the recovery of gastrointestinal function and improve the clinical efficacy. |
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