| 卢莹莹,叶雨辰,王 妍,李香敏,张 鹏.巨噬细胞在肾脏损伤及修复中的作用和机制研究进展[J].,2018,(23):4583-4586 |
| 巨噬细胞在肾脏损伤及修复中的作用和机制研究进展 |
| Advances on the Role and the Regulatory Mechanism of Macrophages in Renal Injury and Repair |
| 投稿时间：2018-05-30 修订日期：2018-06-25 |
| DOI：10.13241/j.cnki.pmb.2018.21.042 |
| 中文关键词: 急性肾损伤 巨噬细胞 单核细胞 肾纤维化 缺血再灌注 |
| 英文关键词: Acute kidney injury Macrophages Monocytes Renal fibrosis Ischemia reperfusion |
| 基金项目:国家自然科学基金项目（81370811, 81530018）；陕西省科学技术发展研究计划项目（2016SF-311） |
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| 中文摘要: |
| 摘要：急性肾损伤（Acute kidney injury, AKI）是一个日益严重的全球性健康问题，然而目前尚无预防AKI或促进AKI恢复的有效的治疗方法，寻找促进肾小管修复、阻止肾纤维化进展的有效治疗靶点与策略已迫在眉睫。巨噬细胞是具有吞噬功能的重要固有免疫细胞，具有高度的起源异质性和功能异质性，在组织发育与稳态、宿主防御、组织损伤与修复以及纤维化等多种生理病理过程中扮演着复杂的角色。特别的，在AKI损伤与修复的不同阶段巨噬细胞发生动态变化并呈现高度多样性。本文就巨噬细胞在肾损伤及修复过程中作用及机制的研究进展作一综述，以期为寻找AKI治疗靶点、制定AKI治疗策略提供新的思路。 |
| 英文摘要: |
| ABSTRACT: Acute kidney injury (AKI) is an increasingly more severe global health problem, but there is still no available methods to prevent its occurence or promote its recovery. It has become urgent to find effective targets and strategies to promote renal tubular re- pair and prevent renal fibrosis progression. Macrophages are important innate immune cells with phagocytic functions. They present sub- stantial heterogeneity of both origins and functions, playing a complex role in multiple physiological and pathological processes including tissue development and homeostasis, host defense, and tissue damage, repair and fibrosis, etc. In particular, the functional status of macrophages vary dynamically at different stages of renal injury and repair with prominent diversity. This article reviews the research ad- vances on the role and the regulatory mechanism of macrophages in renal injury and repair, to provide new ideas for finding therapeutic targets and formulating treatment strategies of AKI. |
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