| 王亚飞,霍龙伟,郑虎林,王 鹏,白晓兵.显微外科手术对颅内动脉瘤患者脑脊液IL-1、IL-6、ET-1、TNF-α和GOS评分的影响[J].,2018,(21):4126-4129 |
| 显微外科手术对颅内动脉瘤患者脑脊液IL-1、IL-6、ET-1、TNF-α和GOS评分的影响 |
| Effects of Microsurgery on the Levels of IL-1, IL-6, ET-1, TNF-α in Cerebrospinal Fluid and GOS of Patients with Intracranial Aneurysms |
| 投稿时间：2018-02-27 修订日期：2018-03-23 |
| DOI：10.13241/j.cnki.pmb.2018.21.028 |
| 中文关键词: 显微外科手术 颅内动脉瘤 近远期疗效 安全性 |
| 英文关键词: Microsurgery Intracranial aneurysm Long term effect Safety |
| 基金项目:陕西省自然科学基金项目(2012C209) |
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| 中文摘要: |
| 摘要 目的：探讨显微外科手术对颅内动脉瘤患者的近远期疗效、安全性及对脑脊液白介素-1(IL-1)、白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、内皮素-1(ET-1)水平和GOS评分的影响。方法：研究对象选取我院2014年8月到2016年1月收治的颅内动脉瘤患者96例，采用随机数字法将其分为对照组和观察组，每组各48例。对照组患者行血管内介入治疗，观察组患者行显微外科手术治疗。比较两组患者的手术时间、术中出血量、住院时间及并发症发生情况，治疗前和治疗后7 d的IL-1、IL-6、TNF-α和ET-1水平，术后随访1年，比较两组的格拉斯哥预后评分(GOS)评分。结果：对照组患者的手术时间、术中出血量、住院时间及并发症发生率均明显低于观察组(P<0.01)；治疗后7 d，观察组患者的脑脊液中IL-1、IL-6、TNF-α、ET-1水平均明显低于对照组(P<0.01)；两组患者的并发症发生率比较差异无明显统计学意义(P>0.05)；术后一年，两组患者的格拉斯哥预后评分(GOS)比较差异无统计学意义(P>0.05)。结论：显微外科手术对颅内动脉瘤的临床效果显著，能明显降低脑脊液IL-1、IL-6、TNF-α和ET-1水平，改善患者预后，且治疗安全性高。 |
| 英文摘要: |
| ABSTRACT Objective: To study the efficacy and safety of microsurgery in the treatment of intracranial aneurysms as well as the ef- fect on cerebrospinal fluid interleukin -1 (IL-1), interleukin -6(IL-6), tumor necrosis factor-α(TNF-α) and endothelin-1(ET-1) levels. Methods: 96 patients with intracranial aneurysms in our hospital from August 2014 to January 2016 were selected and randomly divided into the control group and the observation group with 48 cases in each group. Patients in the control group were treated with endovascular interventional therapy, and the patients in the observation group were treated with microsurgery. The operation time, intraoperative bleed- ing, hospitalization time, incidence of complications, changes of cerebrospinal fluid IL-1, IL-6, TNF-α and ET-1 levels before and after the treatment, Glasgow outcome score at 1 year after surgery were compared between the two groups. Results: The operation time, bleed- ing volume, hospitalization time and the incidence of complications was significantly lower in the observation group (P<0.01) than those of the control group; On the 7th d after treatment, the cerebrospinal fluid IL-1, IL-6, TNF-α and ET-1 levels were significantly lower in the observation group than those of the control group (P<0.01); no obvious difference was found in the incidence of complications be- tween the two groups(P>0.05); at one year after treatment, the Glasgow outcome score (GOS) showed no significant difference between two groups(P>0.05). Conclusion: Microsurgery had a significant effect on intracranial aneurysms, it can significantly reduce the IL-1, IL-6, TNF-α and ET-1 levels in the cerebrospinal fluid, improve the prognosis. |
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