| 郝 月,王春艳,熊 勋,何雅星,刘 琴.血清HE4、FS、SMRP及CA125在卵巢癌患者中的表达及临床意义[J].,2018,(18):3542-3545 |
| 血清HE4、FS、SMRP及CA125在卵巢癌患者中的表达及临床意义 |
| The Expression and Clinical Significance of Serum HE4, FS, SMRP and CA125 in Patients with Ovarian Cancer |
| 投稿时间：2018-03-05 修订日期：2018-03-29 |
| DOI：10.13241/j.cnki.pmb.2018.18.032 |
| 中文关键词: 卵巢癌 血清人附睾蛋白-4 卵泡抑素 可溶性间皮素相关蛋白 糖类抗原125 |
| 英文关键词: Ovarian cancer Human epididymal protein-4 Follistatin Soluble mesothelin related protein Carbohydrate antigen 125 |
| 基金项目:福建省自然科学基金面上项目（2013D0006） |
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| 中文摘要: |
| 摘要 目的：探讨血清人附睾蛋白4（HE4）、卵泡抑素（FS）、可溶性间皮素相关蛋白（SMRP）、糖类抗原125（CA125）在卵巢癌患者中的表达水平及临床意义。方法：选取2014年6月-2017年9月我院收治的卵巢癌患者60例作为卵巢癌组，另选取同期收治的卵巢良性肿瘤患者32例作为良性组，选取同期健康体检妇女40例作为对照组，检测三组受试者血清HE4、FS、SMRP、CA125水平，对比三组HE4、FS、SMRP、CA125阳性表达率，并分析血清HE4、FS、SMRP、CA125对卵巢癌的诊断价值。结果：三组受试者的HE4、FS、SMRP、CA125水平整体对比有统计学意义（P<0.05），其中卵巢癌组与良性组HE4、FS、SMRP、CA125水平高于对照组，且卵巢癌组高于良性组，差异有统计学意义（P<0.05）。三组受试者的HE4、FS、SMRP、CA125阳性表达率整体对比有统计学意义（P<0.05），卵巢癌组与良性组HE4、FS、SMRP、CA125阳性表达率高于对照组，且卵巢癌组高于良性组，差异有统计学意义（P<0.05）。联合检测的灵敏度高于FS、SMRP单项检测，差异有统计学意义（P<0.05），联合检测的特异度高于HE4、FS、SMRP、CA125单项检测，但差异无统计学意义（P>0.05）。结论：卵巢癌患者血清HE4、FS、SMRP、CA125水平及阳性表达率均较高，四项指标联合检测可提高诊断卵巢癌的灵敏度及特异度。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression level and clinical significance of serum epididymal protein-4 (HE4), follistatin (FS), soluble mesothelin associated protein (SMRP) and carbohydrate antigen 125 (CA125) in patients with ovarian cancer. Methods: 60 cases of ovarian cancer who were treated in our hospital from June 2014 to September 2017 were selected as ovarian cancer group, 32 cases of benign ovarian tumor in the same period were selected as benign group, 40 women in healthy physical examination at the same time as a control group. The serum levels of HE4, FS, SMRP and CA125 were detected in the three groups, the positive rates of HE4, FS, SMRP and CA125 in three groups were compared, the value of serum HE4, FS, SMRP and CA125 in the diagnosis of ovarian cancer were analysed. Results: The levels of HE4, FS, SMRP and CA125 in the three groups were statistically significant (P<0.05), among them,the levels of HE4, FS, SMRP and CA125 in the ovarian cancer group and the benign group were higher than those in the control group,the ovarian cancer group was higher than that of the benign group, and the differences were statistically significant (P<0.05). The overall comparison of the positive rates of HE4, FS, SMRP and CA125 in the three groups were statistically significant (P<0.05), the positive ex- pression rate of HE4, FS, SMRP and CA125 in the ovarian cancer group and the benign group were higher than that in the control group, and the ovarian cancer group was higher than the benign group, and the differences were statistically significant (P<0.05). The sensitivity of the combined test was higher than that of FS and SMRP, and the difference was statistically significant (P<0.05), the specificity of the combined test was higher than that of HE4, FS, SMRP and CA125, but the difference was not statistically significant (P>0.05). Conclusion: The serum levels of HE4, FS, SMRP, CA125 and positive expression are higher in the patients with ovarian cancer, the combined detec- tion of four indexes could improve the sensitivity and specificity of the diagnosis of ovarian cancer. |
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