| 王 丹,赵 浩,薛 鸾,孙 宇,侯佳奇.解毒通络生津颗粒联合羟基氯喹对原发性干燥综合征患者血液流变学及血清IgG、IgA、CRP水平的影响[J].,2018,(18):3471-3475 |
| 解毒通络生津颗粒联合羟基氯喹对原发性干燥综合征患者血液流变学及血清IgG、IgA、CRP水平的影响 |
| Effect of Jiedu Tongluo Shengjin Granule Combined with Hydroxychloroquine on Hemorheology and Serum IgG, IgA and CRP Levels in Patients with Primary Sjogren Syndrome |
| 投稿时间：2018-02-17 修订日期：2018-03-12 |
| DOI：10.13241/j.cnki.pmb.2018.18.015 |
| 中文关键词: 解毒通络生津颗粒 羟基氯喹 干燥综合征 疗效 血液流变学 免疫球蛋白 C-反应蛋白 |
| 英文关键词: Jiedu Tongluo Shengjin granule Hydroxychloroquine Sjogren syndrome Curative effect Hemorheology Immunoglobulin C-reactive protein |
| 基金项目:国家自然科学基金青年项目（81503380）；上海市科委中医引导类项目（15401932800） |
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| 摘要 目的：探讨解毒通络生津颗粒联合羟基氯喹对原发性干燥综合征（pSS）患者血液流变学及血清免疫球蛋白G（IgG）、免疫球蛋白A（IgA）、C-反应蛋白（CRP）水平的影响。方法：选取2017年1月-2017年9月期间我院收治的60例pSS患者为研究对象，采用随机数字表法将患者分为对照组（n=30）和观察组（n=30）。对照组给予硫酸羟基氯喹治疗，观察组在此基础上联合解毒通络生津颗粒治疗，比较两组患者的血液流变学指标、IgG、IgA和CRP水平，同时评价两种治疗方案的疗效和不良反应。结果：治疗前两组患者血液流变学指标相比差异均无统计学意义（P>0.05）。治疗后观察组全血高切粘度、全血低切粘度、血浆粘度和红细胞沉降率（ESR）均较治疗前降低，且观察组全血低切粘度和血浆粘度低于对照组（P<0.05）。治疗前两组患者IgG、IgA和CRP水平相比差异均无统计学意义（P>0.05）。治疗后观察组IgG、IgA和CRP水平均较治疗前降低，且低于对照组（P<0.05）。观察组的不良反应发生率为13.33%，低于对照组的46.67%，差异有统计学意义（P<0.05）。对照组总有效率为43.33%，低于观察组的为70.00%，差异有统计学意义（P<0.05）。结论：解毒通络生津颗粒和硫酸羟基氯喹联合应用能够有效改善pSS患者血液流变学及免疫学指标，增强患者免疫力，且安全性较好，值得进一步推广使用。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effects of Jiedu Tongluo Shengjing granule combined with hydroxychloroquine on hemorheology, serum immunoglobulin G (IgG), immunoglobulin A (IgA) and C-reactive protein (CRP) levels in patients with primary sjogren syndrome (pSS). Methods: A total of 60 patients with pSS, who were treated in Yueyang Hospital of Integrated Traditional Chi- nese and Western Medicine from January 2017 to September 2017, were selected and were randomly divided into control group (n=30) and observation group (n=30). The control group was treated with hydroxychloroquine sulfate, and the observation group was treated with Jiedu Tongluo Shengjin granule on the basis of the control group. The hemorheological indexes, levels of IgG, IgA and CRP in the two groups were compared, and the efficacy and adverse reactions of the two treatments were evaluated. Results: There was no signifi- cant difference in hemorheological indexes between the two groups before treatment(P>0.05). After treatment, whole blood high shear viscosity, whole blood low shear viscosity, plasma viscosity and erythrocyte sedimentation rate(ESR) were lower than those before treat- ment, and the whole blood low shear viscosity and plasma viscosity in the observation group were lower than those in the control group (P<0.05). There was no significant difference in the levels of IgG, IgA and CRP between the two groups before treatment (P>0.05). After treatment, the levels of IgG, IgA and CRP in the observation group were lower than those before treatment, which were lower than those in the control group (P<0.05). The incidence of adverse reactions of the observation group was 13.33%, which was lower than that(46.67%) of the control group, and the difference was statistically significant(P<0.05). The total effective rate of the control group was 43.33%, which was lower than that(70.00%) of the observation group, and the difference was statistically significant (P<0.05). Conclusion: Jiedu Tongluo Shengjing granule combined with hydroxychloroquine sulfate can effectively improve hemorheological and immunologi- cal indexes of patients with pSS and enhance immunity of patients, with safety better, which is worthy of further promotion and application. |
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