| 刘 伟,张翠影,何盛江,张铭华,杨 帆,栾和旭.鹿瓜多肽注射液与补肾壮骨胶囊对膝关节骨性关节炎患者血清BALP、BGP、TRACP-5b及CTX-I水平的影响[J].,2018,(16):3127-3130 |
| 鹿瓜多肽注射液与补肾壮骨胶囊对膝关节骨性关节炎患者血清BALP、BGP、TRACP-5b及CTX-I水平的影响 |
| Clinical Efficacy of Lugu Peptide Injection Combined with Bushenzhuanggu Capsule on Knee Joint Osteoarthritis and Effect on the Serum BALP, BGP, TRACP-5b and CTX-I Levels |
| 投稿时间：2017-10-19 修订日期：2017-11-13 |
| DOI：10.13241/j.cnki.pmb.2018.16.028 |
| 中文关键词: 鹿瓜多肽注射液 补肾壮骨胶囊 膝关节骨性关节炎 |
| 英文关键词: Lugu Peptide Injection Bushen Zhuanggu Capsule Knee Joint Osteoarthritis |
| 基金项目:重庆市教委科研基金项目(KJ1702023) |
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| 中文摘要: |
| 摘要 目的：研究鹿瓜多肽注射液联合补肾壮骨胶囊对膝关节骨性关节炎的临床疗效及对血清骨特异性碱性磷酸酶(BALP)、骨钙素(BGP)、抗酒石酸盐酸性磷酸酶异构体5b(TRACP-5b)、I型胶原C 端肽(CTX-I)水平的影响。方法：选取2015年4月至2016年3月我院收治的84例膝关节骨性关节炎患者，根据患者入院顺序分为观察组和对照组，42例每组。对照组使用鹿瓜多肽注射液，观察组在此基础上加以补肾壮骨胶囊。比较两组患者临床疗效，治疗前后血清BALP、BGP、TRACP-5b、CTX-I水平、视觉模拟评分法(VAS)的变化。结果：治疗后，观察组临床总有效率显著高于对照组[90.48%(38/42)比64.29%(27/42)] (P<0.05)；两组患者血清BALP、BGP水平均较治疗前显著升高(P<0.05)，血清TRACP-5b、CTX-I水平、VAS评分均较治疗前显著降低(P<0.05)，且观察组的血清BALP、BGP水平显著高于对照组(P<0.05)，血清TRACP-5b、CTX-I水平、VAS评分明显低于对照组(P<0.05)。结论：鹿瓜多肽注射液联合补肾壮骨胶囊治疗膝关节骨性关节炎的临床疗效明显优于鹿瓜多肽注射液单药治疗，其能显著升高患者的血清BALP、BGP水平，降低血清RACP-5b、CTX-I水平，改善患者骨代谢。 |
| 英文摘要: |
| ABSTRACT Objective: To study the efficacy of Lugu Peptide Injection combined with Bushenzhuanggu Capsule on the knee osteoarthritis and effect on the serum bone specific alkaline phosphatase (BALP), osteocalcin (BGP), tartrate Phosphatase isoform 5b (TRACP-5b), type I collagen C-terminal peptide (CTX-I) levels. Methods: From April 2015 to March 2016, 84 cases of patients with knee osteoarthritis were divided into the observation group and the control group. The control group was treated with lugua peptide injection, and the observation group was supplemented with Kidney Zhuanggu Capsule. The clinical efficacy, changes of serum BALP, BGP, TRACP-5b, CTX-I levels and visual analogue scale (VAS) before and after treatment were compared between the two groups. Results: After treatment, the total effective rate of observation group was significantly higher in the observation group than that of the control group [90.48% (38/42) vs 64.29% (27/42)] (P<0.05). Compared with before treatment, the serum levels of BALP and BGP were significantly higher in both groups after treatment(P<0.05). The serum TRACP-5b, CTX-I levels and VAS scores were significantly lower than those before treatment (P<0.05). The levels of serum BALP and BGP in the observation group were significantly higher than those in the control group (P<0.05), the serum TRACP-5b, CTX-I levels and VAS scores were significantly lower in the observation group than those in the control group (P<0.05). Conclusion: The clinical efficacy of Lugua Peptide Injection combined with Bushenzhuanggu Capsule in the treatment of knee osteoarthritis is superior to that of Lugu polypeptide injection, which can significantly increase the serum BALP and BGP levels, decrease the serum RACP-5b, CTX-I levels and improve the bone metabolism. |
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