| 马 丽,李秀君,曾丽梅,梅 林,吴易聪.血液透析联合血液灌流治疗急性肾损伤患者的疗效及对生化指标的影响[J].,2018,(15):2950-2953 |
| 血液透析联合血液灌流治疗急性肾损伤患者的疗效及对生化指标的影响 |
| Effect of Hemodialysis Combine with Hemoperfusion on the Treatment of Acute Kidney Injury and its Influence on the Biochemical Idexes of the Patients |
| 投稿时间：2017-11-29 修订日期：2017-12-23 |
| DOI：10.13241/j.cnki.pmb.2018.15.033 |
| 中文关键词: 急性肾损伤 血液透析 血液灌流 疗效 生化指标 |
| 英文关键词: Acute kidney injury Hemodialysis Hemoperfusion Clinical Effect Biochemical indexes |
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| 中文摘要: |
| 摘要 目的：探讨血液透析（HD）联合血液灌流（HF）治疗对急性肾损伤（AKI）患者的疗效以及对生化指标的影响。方法：选取2016年1月-2017年2月在我院进行治疗的AKI患者56例，按随机数字表法分为对照组和观察组，每组各28例。对照组进行HD治疗，观察组进行HD联合HF治疗。治疗1个月后，比较两组患者血肌酐（Scr）、血尿素氮（BUN）以及炎症因子水平，检验治疗疗效差异，并统计并发症发生情况。结果：治疗前，两组患者的Scr、BUN、C反应蛋白（CRP）、肿瘤坏死因子-α（TNF-α）和白细胞介素-2（IL-2）水平无明显差异（P>0.05），治疗1个月后，两组患者的Scr、BUN、CRP、TNF-α和IL-2水平均较治疗前明显降低，且观察组的上述指标均较对照组降低（P<0.05）；观察组的总有效率明显高于对照组（89.29% vs 64.29%）（P<0.05）；观察组并发症发生率为3.57%，明显低于对照组的21.43%（P<0.05）。结论：HD联合HF治疗AKI患者具有较好的临床疗效，且能显著改善患者生化指标，控制炎症反应，较单用HD治疗优势明显，且安全性更高，值得临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To explore the effect of hemodialysis (HD) combine with hemoperfusion (HF) on the treatment of acute kidney injury (AKI) and its influence on the biochemical indexes of the patients. Methods: 56 patients with AKI who were treated in our hospital from January 2016 to February 2017 were selected, and they were randomly divided into control group and observation group according to the random number table method, 28 cases in each group. The control group was treated with HD, and the observation group was treated with HD combined with HF. At 1 month after treatment, the levels of serum creatinine (Scr), blood urea nitrogen (BUN) and inflammatory factors were compared between the two groups, the difference of treatment effect was observed, and the complications were observed. Results: Before treatment, there was no significant difference in Scr, BUN, C reactive protein (CRP), tumor necrosis fac- tor-α (TNF-α) and interleukin-2 (IL-2) between the two groups (P>0.05). At 1 month after treatment, the levels of Scr, BUN, CRP, TNF-α and IL-2 in the two groups were significantly decreased, and the above indexes in the observation group were significantly lower than those in the control group (P<0.05). The total effective rate of the observation group was significantly higher than that of the control group (89.29% vs 64.29%) (P<0.05). The complication rate of the observation group was 3.57%, which was significantly lower than that of the control group (21.43%) (P<0.05). Conclusion: HD combined with HF has good clinical efficacy in the treatment of AKI, and it can significantly improve the patient's biochemical indicators, control inflammatory response. Compared with HD alone, the advantages of treatment are obvious, and the safety is higher, which is worthy of clinical application. |
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