| 路聪哲,陈 洪,伏婷婷,任冰稳,杜凯音,华 伟,王 吉,张宝和.老年支气管哮喘患者血清25-羟维生素D3浓度与免疫功能及肺功能的相关性研究[J].,2018,(15):2910-2913 |
| 老年支气管哮喘患者血清25-羟维生素D3浓度与免疫功能及肺功能的相关性研究 |
| Correlation of Serum 25- Hydroxyvitamin D3 Concentration with Immune Function and Pulmonary Function in Elderly Patients with Bronchial Asthma |
| 投稿时间：2018-03-01 修订日期：2018-03-24 |
| DOI：10.13241/j.cnki.pmb.2018.15.023 |
| 中文关键词: 支气管哮喘 老年 25-羟维生素D3 免疫功能 肺功能 相关性 |
| 英文关键词: Bronchial asthma Elderly 25- hydroxyvitamin D3 Immune function Pulmonary function Correlation |
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| 中文摘要: |
| 摘要 目的：研究老年支气管哮喘患者血清25-羟维生素D3[25-（OH）D3]浓度与免疫功能及肺功能的关系。方法：选取2016年1月至2017年12月我院收治的老年支气管哮喘患者96例作为研究组，根据肺功能检查结果分为轻度哮喘组（n=30）、中度哮喘组（n=38）和重度哮喘组（n=28），另选取同期在我院进行体检的健康老年人40例作为对照组。比较各组血清25-（OH）D3浓度、第一秒最大呼气量占用力肺活量百分比（FEV1/FVC）、FEV1占预计值百分比（FEV1%pred）、CD4+、CD8+、CD4+/CD8+以及血清免疫球蛋白A（IgA）、免疫球蛋白M（IgM）、免疫球蛋白G（IgG）水平，并分析血清25-（OH）D3与免疫功能指标及肺功能指标的相关性。结果：研究组血清25-（OH）D3浓度、FEV1%pred水平均低于对照组（P＜0.05），两组FEV1/FVC水平比较差异无统计学意义（P>0.05）。研究组CD4+、CD4+/CD8+、血清IgA、IgM、IgG水平均低于对照组，CD8+水平高于对照组（P＜0.05）。重度哮喘组血清25-（OH）D3、IgA、IgM、IgG水平、FEV1%pred、CD4+、CD4+/CD8+均低于中度哮喘组和轻度哮喘组，中度哮喘组又低于轻度哮喘组（P＜0.05），重度哮喘组CD8+水平高于中度哮喘组和轻度哮喘组，中度哮喘组又高于轻度哮喘组（P＜0.05）。经Pearson相关性分析可得：老年支气管哮喘患者血清25-（OH）D3与FEV1%pred、CD4+、CD4+/CD8+、IgA、IgM、IgG均呈正相关（P＜0.05），与CD8+呈负相关（P＜0.05）。结论：老年支气管哮喘患者的血清25-（OH）D3浓度显著降低，且与肺功能和免疫功能相关，25-（OH）D3浓度的检测可用于评估患者病情严重程度。 |
| 英文摘要: |
| ABSTRACT Objective: To study the Correlation of serum 25- hydroxyvitamin D3 [25-（OH）D3]concentration with immune func- tion and pulmonary function in elderly patients with bronchial asthma. Methods: 96 elderly patients with bronchial asthma who were treated in our hospital from January 2016 to December 2017 were selected as the research group, the patients were divided into mild asth- ma group (n=30), moderate asthma group (n=38) and severe asthma group (n=28) according to the pulmonary function test results, 40 healthy elderly people who have been examined in our hospital for the same period as the control group. The serum 25- (OH) D3, maxi- mum expiratory volume in first second (FEV1/FVC), FEV1 account for the percentage of estimated value (FEV1%pred), CD4+, CD8+, CD4+/CD8+, serum immunoglobulin A (IgA), immunoglobulin M (IgM) and immunoglobulin G (IgG) level were compared, the correla- tion between serum 25- (OH) D3 and the immune function index and pulmonary function index were analyzed. Results: The serum levels of 25- (OH) D3 and FEV1% pred in the research group were lower than those in the control group (P<0.05), there was no significant dif- ference between the two groups of FEV1/FVC levels (P>0.05). The level of CD4+, CD4+/CD8+, serum IgA, IgM and IgG in the research group were all lower than those in the control group, and the level of CD8+ was higher than that of the control group (P<0.05). The levels of serum 25- (OH) D3, IgA, IgM, IgG, FEV1%pred, CD4+ and CD4+/CD8+ in severe asthma group were lower than those in moderate asthma group and mild asthma group, while those in moderate asthma group were lower than those in mild asthma group (P<0.05), the level of CD8+ in severe asthma group was higher than that in moderate asthma group and mild asthma group, and the moderate asthma group was higher than that of mild asthma group (P<0.05). Pearson correlation analysis showed that the serum 25- (OH) D3 was positively correlated with FEV1%pred, CD4+, CD4+/CD8+, IgA, IgM and IgG in elderly patients with bronchial asthma (P<0.05), and negatively cor- related with CD8+ (P<0.05). Conclusion: The serum 25- (OH) D3 concentration of the elderly patients with bronchial asthma is signifi- cantly lower, and it is related to the pulmonary function and immune function, the detection of 25- (OH) D3 concentration can be used to assess the severity of the patient's condition. |
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