| 陈剑雄,张 辉,李卓成,刘远智,刘全英.孕早期妇女血清25-羟维生素D水平的表达及与甲状腺功能的相关性研究[J].,2018,(12):2360-2364 |
| 孕早期妇女血清25-羟维生素D水平的表达及与甲状腺功能的相关性研究 |
| Expression of Serum 25 (OH) D Levels in Early Pregnancy Women and Its Correlation with Thyroid Function |
| 投稿时间：2018-01-07 修订日期：2018-01-30 |
| DOI：10.13241/j.cnki.pmb.2018.12.034 |
| 中文关键词: 孕早期 25-羟维生素D 甲状腺功能 相关性 |
| 英文关键词: Early pregnancy 25-hydroxyvitamin D Thyroid function Correlation |
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| 中文摘要: |
| 摘要 目的：探讨孕早期妇女血清25-羟维生素D [25(OH)D]水平及与甲状腺功能的相关性。方法：选取2015年12月至2016年12月期间来我院进行常规产前检查的孕早期（≤12周）妇女90例为观察组，根据妊娠时间将观察组分为A组（4-6周）、B组（7-9周）和C组（10-12周），另选取同期在我院进行健康体检的妇女30例为对照组。采用电化学发光免疫分析法测定所有研究对象血清中的25(OH)D、促甲状腺激素（TSH）、游离甲状腺素（FT4）、游离三碘甲状腺原氨酸（FT3）水平，并分析观察组妇女血清25(OH)D水平与TSH、FT4、FT3之间的相关性。结果：A组、B组、C组出现维生素D缺乏的比例高于对照组，维生素D充足的比例低于对照组，C组出现维生素D不足的比例高于对照组，差异均有统计学意义（P<0.05）。A组、B组、C组维生素D缺乏、维生素D不足、维生素D充足的比例之间差异无统计学意义（P>0.05）。A组、B组、C组出现甲状腺功能异常的比例比较差异无统计学意义（P>0.05）。三种甲状腺功能减退的患病率由低到高分别为临床甲减、亚临床甲减、低T4血症，且A组、B组、C组临床甲减、亚临床甲减及低T4血症组间整体比较差异无统计学意义（P>0.05）。不同血清25(OH)D水平的观察组孕妇血清中TSH、FT4、FT3水平之间的差异无统计学意义（P>0.05）。直线回归分析显示，观察组血清中25(OH)D水平与TSH、FT4无明显相关性（P>0.05），与FT3呈正相关关系（P<0.05），多元线性回归模型分析显示血清中25(OH)D水平与TSH、FT4、FT3均无相关性（P>0.05）。结论：孕早期妇女普遍存在维生素D缺乏的现象，血清25(OH)D水平及与甲状腺功能无明显相关性，但仍应注意加强维生素D的补充。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the expression of serum 25-hydroxyvitamin D [25(OH)D] and its correlation with thyroid function in early pregnancy women. Methods: A total of 90 early pregnancy (≤12 weeks) women, who took early prenatal examination in the Second People's Hospital of Shenzhen from December 2015 to December 2016, were selected as observation group. According to the time of pregnancy, the observation group was further divided into group A (4-6 weeks), group B (7-9 weeks) and group C (10-12 weeks). Another 30 women conducting physical examination in this hospital in the same period were selected as the control group. The serum levels of 25(OH)D, thyroid stimulating hormone (TSH), free thyroxine (FT4), and free three iodinated thyroid (FT3) of all the sub- jects were detected by electrochemiluminescence immunoassay. The correlation between the levels of serum 25 (OH) D and TSH, FT4, and FT3 in the observation group was analyzed. Results: The proportion of vitamin D deficiency in group A,group B and group C was higher than that in the control group, the differences were statistically significant (P<0.05). There was no significant difference in the pro- portion of abnormal thyroid function among group A, B and C (P>0.05). The prevalence rate from low to high was hypothyroidism, sub- clinical hypothyroidism and low T4 respectively, and there was no significant difference in hypothyroidism, subclinical hypothyroidism and low T4 among group A, B and C (P>0.05). There was no significant difference between the serum levels of TSH, FT4 and FT3 in the observation group with different serum levels of 25(OH)D (P>0.05). Linear regression analysis showed that the serum levels of 25(OH)D in the observation group had no significant correlation with TSH and FT4 (P>0.05), and was positively correlated with FT3 (P<0.05).Multiple linear regression analysis showed that there was no correlation between 25(OH)D levels and TSH, FT4, TSH(P>0.05). Conclusion: Vitamin D deficiency is common in early pregnancy women, and the expression of serum 25(OH)D levels is not significantly corre- lated with thyroid function, but vitamin D supplementation should still be strengthened. |
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