| 黄增光,荣 震,石 玮,李春姗,陈 莲.ER、PR、CA-153、Ki-67的表达与乳腺癌临床病理特征及预后的相关性研究[J].,2018,(10):1948-1951 |
| ER、PR、CA-153、Ki-67的表达与乳腺癌临床病理特征及预后的相关性研究 |
| Correlation Between Expression of ER, PR, CA-153, Ki-67 and Clinic Pathological Features and Prognosis of Breast Cancer |
| 投稿时间：2018-01-08 修订日期：2018-01-30 |
| DOI：10.13241/j.cnki.pmb.2018.10.029 |
| 中文关键词: 乳腺癌 雌激素受体 孕激素受体 糖类抗原-153 Ki-67 |
| 英文关键词: Breast cancer Estrogen receptor Progesterone receptor Carbohydrate antigen-153 Ki-67 |
| 基金项目:广西医疗卫生适宜技术研究与开发项目（S201308-03） |
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| 中文摘要: |
| 摘要 目的：研究雌激素受体（ER）、孕激素受体（PR）、糖类抗原-153（CA-153）、Ki-67的表达与乳腺癌临床病理特征及预后的相关性。方法：选取2015年3月-2017年4月我院收治的乳腺癌患者190例为研究对象。分别采用免疫组化法检测患者ER、PR、Ki-67表达情况，采用酶联免疫吸附法检测CA-153表达情况。分析上述四项指标的表达与临床病理特征的关系，并作指标间的相关性分析。结果：有淋巴结转移的乳腺癌组织中ER、PR阳性率明显高于无淋巴结转移，差异有统计学意义（P<0.05），而年龄、肿瘤大小、TNM分期不同的乳腺癌组织中ER、PR阳性率比较差异均无统计学意义（P>0.05）。肿瘤大小>2cm、TNM分期为Ⅲ-Ⅳ期、有淋巴结转移乳腺癌组织中CA-153阳性率分别高于肿瘤大小≤2cm、TNM分期为Ⅰ-Ⅱ期、无淋巴结转移，差异均有统计学意义（P<0.05），而年龄不同的乳腺癌组织中CA-153阳性率比较差异无统计学意义（P>0.05）。TNM分期为Ⅲ-Ⅳ期、有淋巴结转移乳腺癌组织中Ki-67阳性率明显高于TNM分期为Ⅰ-Ⅱ期、无淋巴结转移，差异均有统计学意义（P<0.05），而年龄、肿瘤大小不同的乳腺癌组织中Ki-67阳性率比较差异无统计学意义（P>0.05）。经Pearson相关性分析显示，ER、PR、CA-153、Ki-67在乳腺癌中表达均呈正相关（P<0.05）。结论：临床工作中可通过联合检测ER、PR、CA-153、Ki-67的表达情况，从而有效判断乳腺癌患者的病情严重程度以及转移情况，值得临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To study the correlation between the expression of estrogen receptor (ER), progesterone receptor (PR), car- bohydrate antigen-153 (CA-153), ki-67 and clinic opathological features and prognosis of breast cancer. Methods: A total of 190 patients with breast cancer, who were treated in First Affiliated Hospital of Guangxi University of Chinese Medicine from March 2015 to April 2017, were selected as research subjects. The expression of ER, PR and ki-67 were detected by immunohistochemistry; the expression of CA-153 was detected by enzyme-linked immunosorbent assay. The relationship between the expression of the above four indexes and the clinicopathological features was analyzed, and the correlation between the indexes was analyzed. Results: The positive rates of ER and PR in breast cancer tissues with lymph node metastasis were significantly higher than those without lymph node metastasis, and the dif- ference was statistically significant (P<0.05). The positive rate of CA-153 in breast cancer tissues with tumor size >2 cm, TNM stage III- IV stage and lymph node metastatic were higher than that with tumor size ≤2 cm, TNM stage I-II stage, and without lymph node metas- tasis, the difference was statistically significant (P<0.05); there was no significant difference in the positive rate of CA-153 in the breast cancer tissues of different ages (P>0.05). The positive rate of Ki-67 in breast cancer tissues with TNM stage III-IV stage and lymph node metastasis was significantly higher than that with TNM stage I-II stage and without lymph node metastasis, the difference was statistically significant (P<0.05); there was no significant difference in the positive rate of Ki-67 in breast cancer tissues of different age and tumor size (P>0.05). The Pearson correlation analysis showed that the expression of ER, PR, CA-153 and Ki-67 were positively correlated in breast cancer (P<0.05). Conclusion: In clinical work, combination of detecting the expression of ER, PR, CA-153 and Ki-67 can effectively predict the severity and metastasis of patients with breast cancer, which is worthy of clinical application. |
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