| 秦逸辉,邹 健,李 毅,王 军,余 研,吴志峰.高压氧联合神经节苷脂对高血压脑出血患者术后的影响[J].,2018,(10):1944-1947 |
| 高压氧联合神经节苷脂对高血压脑出血患者术后的影响 |
| Effect of Hyperbaric Oxygenation Combined with Ganglioside on the Hypertensive Cerebral Hemorrhage Patients with Microinvasive Evacuation of Hematoma |
| 投稿时间：2017-12-07 修订日期：2017-12-29 |
| DOI：10.13241/j.cnki.pmb.2018.10.028 |
| 中文关键词: 高血压 脑出血 微创血肿清除术 高压氧 神经节苷脂 |
| 英文关键词: Hypertension Cerebral hemorrhage Microinvasive evacuation of hematoma Hyperbaric oxygenation Ganglioside |
| 基金项目:国家自然科学基金面上项目（81572468） |
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| 中文摘要: |
| 摘要 目的：分析高压氧联合神经节苷脂对高血压脑出血患者微创血肿清除术后的临床疗效。方法：选择2012年1月-2016年10月我院收治的高血压脑出血患者100例，根据随机数字表法分成观察组、对照组，每组各50例。所有患者均先行微创血肿清除术，对照组患者术后24 h内确定体征平稳，病情稳定后给予高压氧治疗，观察组在对照组治疗方法的基础之上加用神经节苷脂。比较两组患者的临床疗效、治疗前后神经功能缺损评分(NIHSS)、脑水肿体积、血清基质金属蛋白酶-9(MMP-9)、S100β蛋白及神经生长因子(NGF)的水平的变化及术后3个月时的日常生活活动能力。结果：治疗后，观察组的基本痊愈率显著高于对照组(P<0.05)，两组NIHSS评分都较治疗前显著降低，且观察组NIHSS评分显著低于对照组(P均<0.05)。两组手术后第7 d、14 d及28 d的脑水肿体积均显著低于治疗前(P<0.05)，且观察组各时间点的脑水肿体积均显著低于对照组(P<0.05)。两组血清MMP-9、S100β均较治疗前降低(P<0.05)，NGF较治疗前升高(P<0.05)，且观察组治疗后的血清MMP-9、S100β水平显著低于、血清NGF水平显著高于对照组(P<0.05)。观察组患者术后3个月时的日常生活活动能力总良好率显著高于对照组(P<0.05)。结论：高压氧联合神经节苷脂辅助微创血肿清除术治疗高血压脑出血临床疗效显著，有利于改善患者预后。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the effect of hyperbaric oxygenation combined with ganglioside on the hypertensive cerebral hemorrhage patients with microinvasive evacuation of hematoma. Methods: 100 cases of hypertensive cerebral hemorrhage patients with microinvasive evacuation of hematoma in our hospital from January 2012 to October 2016 were divided into the observation group and the control group, 50 cases in each group. Patients in the control group were treated with hyperbaric oxygenation after microinva- sive evacuation of hematoma, and the observation group were treated with hyperbaric oxygenation combined with ganglioside. The clini- cal effect, neurological function deficits scale(NIHSS), edema volume in brain, serum levels of MMP-9,S100β, NGF, and the ability of daily life activities at three months after operation were compared between two groups. Results: The recovered rate of observation group was significantly higher than that of the control group(P<0.05). After treatment, the NIHSS scores, edema volume, serum levels of MMP-9, S100β of both groups were significantly lower than those before treatment (P<0.05), which were significantly lower in the ob- servation group than those in the control group (P<0.05), and the serum levels of NGF in both groups were significantly higher than those before treatment (P<0.05), which was significantly higher in the observation group than that in the control group(P<0.05). It was found during the follow up that the excellent rate of ability of daily life of observation group was significantly higher than that of the control group (P<0.05). Conclusion: Hyperbaric oxygenation combined with ganglioside had remarkably efficacy to treat cerebral hemorrhage patients after microinvasive evacuation of hematoma, it was advantageous for improving the prognosis of patients. |
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