| 汪志举,王俊生,张 鹏,赵 磊,刘庆锴.骨肽注射液对四肢骨折患者骨代谢、红细胞相关指标及炎性因子水平的影响[J].,2018,(9):1767-1771 |
| 骨肽注射液对四肢骨折患者骨代谢、红细胞相关指标及炎性因子水平的影响 |
| Influence of Ossotide Injection on Bone Metabolism, Erythrocyte Related Indexes and Inflammatory Factor Levels in Patients with Limb Fracture |
| 投稿时间：2017-12-12 修订日期：2017-12-31 |
| DOI：10.13241/j.cnki.pmb.2018.09.036 |
| 中文关键词: 四肢骨折 骨肽注射液 骨代谢 红细胞相关指标 炎性因子 |
| 英文关键词: Limb fracture Ossotide injection Bone metabolism Erythrocyte related index Inflammatory factor |
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| 摘要 目的：研究骨肽注射液对四肢骨折患者骨代谢、红细胞相关指标及炎性因子水平的影响。方法：选取2015年4月-2017年4月我院收治的四肢骨折患者84例，将其以随机数字表法分成研究组（n=42）与对照组（n=42）。对照组予以常规治疗，研究组则在常规治疗的基础上予以骨肽注射液治疗。分别比较两组骨折愈合时间、治疗前后骨代谢、红细胞相关指标以及炎性因子水平变化情况。结果：研究组上肢骨折、下肢骨折愈合时间分别少于对照组（P<0.05）。治疗4周后研究组骨碱性磷酸酶（BALP）、Ⅰ型前胶原羟基端前肽（PICP）、骨钙素（BGP）水平均高于对照组和治疗前，而Ⅰ型胶原羟基端肽β特殊序列（β-CTX）水平低于对照组和治疗前（P<0.05）。治疗4周后研究组红细胞积聚指数（EAI）、红细胞电泳指数（EEI）水平均低于对照组和治疗前，而红细胞免疫促进因子（RFER）、直向肿瘤红细胞花环率（DTER）水平较对照组和治疗前均升高（P<0.05）。治疗4周后两组患者C反应蛋白（CRP）、白细胞介素-6（IL-6）、肿瘤坏死因子-α（TNF-α）水平均低于治疗前，且研究组CRP、TNF-α水平较对照组降低（P<0.05）。结论：骨肽注射液应用于四肢骨折患者中可促进骨折愈合，改善骨代谢、红细胞相关指标以及炎性因子水平，值得临床推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To study influence of ossotide injection on bone metabolism,erythrocyte related indexes and inflammatory factor levels in patients with limb fracture. Methods: A total of 84 patients with limb fracture, who were treated in Chifeng Municipal Hospital from April 2015 to April 2017, were selected and randomly divided into study group (n=42) and control group (n=42). The con- trol group was given routine treatment, the study group was given ossotide injection on the basis of routine treatment. The time of fracture healing, bone metabolism, erythrocyte related indexes and the levels of inflammatory factors in the two groups before and after treatment were compared. Results: The healing time of upper limb fracture and lower limb fracture in the study group was less than that of the con- trol group(P<0.05). After 4 weeks of treatment, the levels of bone alkaline phosphatase (BALP), procollagen carboxyterminal propeptide (PICP) and bone gla protein (BGP) in the study group were higher than those in the control group and before treatment, but the levels of β-isomer of the C-terminal telopeptide of typeⅠcollagen (β-CTX) was lower than those in the control group and before treatment (P<0.05). After 4 weeks of treatment, the erythrocyte electrophoresis index (EAI) and erythrocyte electrophoresis index (EEI) were lower than those in the control group and before treatment,and rosette forming enhancing rate (RFER) and direct tumor erythrocyte rosette rate (DTER) were higher than those in the control group and before treatment (P<0.05). After 4 weeks of treatment, the levels of C reactive protein (CRP), interleukin-6 (IL-6) and tumor necrosis factor-α (TNF-α) in the two groups were all lower than those before treatment, and the levels of CRP and TNF-α in the study group were lower than those in the control group (P<0.05). Conclusion: The application of ossotide injection in the patients with limb fracture can promote fracture healing and improve bone metabolism, erythrocyte related in- dexes and inflammatory cytokines, which is worthy of clinical application. |
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