| 孙思文,庄丽维,米丽娜,薄挽澜,李 霞.胃底腺息肉的研究进展[J].,2018,(8):1597-1600 |
| 胃底腺息肉的研究进展 |
| Study of Gastric Fundus Gland Polyps |
| 投稿时间：2017-06-28 修订日期：2017-07-23 |
| DOI：10.13241/j.cnki.pmb.2018.08.042 |
| 中文关键词: 胃底腺息肉 女性 家族性腺瘤性息肉病 质子泵抑制剂 |
| 英文关键词: Fundic gland polyps Females Familial adenomatous polyposis Proton pump inhibitor |
| 基金项目:黑龙江省教育厅科研基金项目（11551246） |
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| 中文摘要: |
| 摘要：胃底腺息肉是指胃底胃体粘膜形成的多发性广基息肉样隆起，为胃体腺上皮的增生。国内外研究均证明本病高发于40-60岁女性，年龄及性别差异显著。过去认为本病的发生与家族性腺瘤性息肉病密切相关，但近年来人们认为无家族性腺瘤性息肉病的人群也可以发生胃底腺息肉。国内外学者们研究了家族性腺瘤性息肉病、Helicobacter pylori感染、质子泵抑制剂的应用、?茁-连环蛋白基因变异、胆汁反流等与本病发生的相关性，有学者认为Hp感染与疾病发生成负相关，质子泵抑制剂的长期应用会导致疾病的发生，β-catenin基因突变影响了APC/β-catenin途径，从而导致胃底腺息肉的产生。目前对于疾病发生的相关危险因素及发病机制，国内外仍无定论。本文将近年来中外学者的研究加以总结并提出进一步设想。 |
| 英文摘要: |
| ABSTRACT: Fundic gland polyps is refers to the mucous membrane of stomach bottom body formed by multiple wide base polypoid, uplift of the gastric body gland epithelial hyperplasia. Domestic and foreign studies have proved a high incidence of this disease in females aged from 40 to 60 years old, the age and sex were significantly different. Over the past the incidence of this disease is considered closely associated with familial adenomatous polyposis, but in recent years we found no familial adenomatous polyposis population can also had gastric gland polyps. Researchers studied the familial adenomatous polyposis, Hp infection, the application of proton pump inhibitors, β- catenin gene mutation and bile reflux of correlation with the disease, some study believe that Hp infection is negatively correlated with this disease, a long term use of proton pump inhibitors can lead to the occurrence of disease, the β- catenin gene mutation affects the APC / β- catenin pathway, then leads to the generation of the gastric fundus. But the risk factors associated with disease occurrence and pathogenesis, is still inconclusive around the world. This review is to summarize the research progress of this disease and put forward the idea further. |
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