| 闫学平,郝秀丽,孙 婷,齐如艳,李绍刚,赵秋芬.血常规联合hs-CRP、免疫学指标检测在小儿急性上呼吸道感染中的临床价值[J].,2018,(8):1502-1505 |
| 血常规联合hs-CRP、免疫学指标检测在小儿急性上呼吸道感染中的临床价值 |
| Clinical Value of Blood Routine Combined with hs-CRP and Immunological Indicators for the Acute upper Respiratory Tract Infection in Children |
| 投稿时间：2017-10-12 修订日期：2017-10-31 |
| DOI：10.13241/j.cnki.pmb.2018.08.020 |
| 中文关键词: 小儿急性上呼吸道感染 血常规 hs-CRP 免疫学指标 临床价值 |
| 英文关键词: Acute upper respiratory tract infection of children Blood routine hs-CRP Immunological indicators Clinical value |
| 基金项目:国家卫生计生委临床科研专项（W2016EWQT39） |
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| 中文摘要: |
| 摘要 目的：探讨血常规联合超敏C-反应蛋白(hs-CRP)、免疫学指标检测在小儿急性上呼吸道感染中的临床价值。方法：以2013年3月至2017年6月我院收治的185例急性上呼吸道感染患儿为研究对象，根据病原体类型分为病毒组87例、细菌组64例、支原体组34例，并选择同期在我院体检的健康儿童80例作为健康组。检测和比较四组的白细胞计数(WBC)、血清hs-CRP和T淋巴细胞水平。结果：细菌组的hs-CRP水平和WBC高于其它三组(P＜0.05)，病毒组和支原体组的hs-CRP水平高于健康组(P＜0.05)，病毒组的WBC低于且支原体组的WBC高于健康组(P＜0.05)，病毒组的WBC低于支原体组(P＜0.05)；病毒组、细菌组和支原体组的CD4+和CD4+/CD8+低于且CD8+高于健康组(P＜0.05)，但病毒组、细菌组和支原体组组间差异无统计学意义(P＞0.05)；WBC、hs-CRP和T淋巴细胞联合检测的灵敏度和准确度高于各单项检测(P＜0.05)，WBC、hs-CRP和T淋巴细胞联合检测的灵敏度高于两两联合检测(P＜0.05)，且准确度略高于两两联合检测，WBC、hs-CRP和T淋巴细胞联合检测的特异度低于hs-CRP和T淋巴细胞单项检测(P＜0.05)，且略低于WBC单项检测。结论：WBC和hs-CRP有利于鉴别感染病原体的种类，急性上呼吸道感染患儿存在一定程度的细胞免疫失调，而在WBC和hs-CRP检测的基础上联合免疫学指标有利于提高对小儿急性上呼吸道感染的检测灵敏度和准确度。 |
| 英文摘要: |
| ABSTRACT Objective: To discuss the clinical value of blood routine combined with hs-CRP and immunological indicators for acute upper respiratory tract infection of children. Methods: A total of 185 children with acute upper respiratory tract infection from March 2013 to June 2017were studied and divided into virus group (87 cases), bacteria group (64 cases), mycoplasma group (34 cases) according to the pathogen type. And 80 healthy children in our hospital were selected as health group. The white blood cell count (WBC), hs-CRP and T lymphocytes were analyzed of four groups. Results: The hs-CRP level and WBC of bacteria group was higher than other three groups (P＜0.05), hs-CRP level of virus group and mycoplasma group were higher than health group (P＜0.05), WBC of virus group was lower and mycoplasma group was higher than health group (P＜0.05), WBC of virus group was lower than mycoplasma group (P＜0.05); CD4+ and CD4+/CD8+ of virus group, bacteria group and mycoplasma group were lower and CD8+ was higher than health group (P＜0.05), but there was no statistically significant difference between the virus group, bacterial group and mycoplasma group (P＜0.05); The sensitivity and accuracy of WBC, hs-CRP and T lymphocytes joint detection were higher than single detection (P＜0.05), and the sensitivity of WBC, hs-CRP and T lymphocytes joint detection was slightly higher than two joint detection, the specificity of WBC, hs-CRP and T lymphocytes joint detection was lower than single hs-CRP and T lymphocytes detection (P＜0.05), and the specificity of WBC, hs-CRP and T lymphocytes joint detection was slightly lower than single WBC detection. Conclusion: The WBC and hs - CRP are helpful to identify the types of pathogen, acute upper respiratorychildren show cell immune disorders. Immunological index is helpful to improve detection sensitivity and accuracy of acute upper respiratory tract infection. The immunological indicators detection can improve the detection sensitivity and accuracy for acute upper respiratory tract infection of children based on blood routine combined with hs-CRP detection. |
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