| 曹悦悦,万玉骁,李 阳,魏 巍,朱俊超.关于新生儿缺血缺氧性脑病的研究进展[J].,2018,(3):585-587 |
| 关于新生儿缺血缺氧性脑病的研究进展 |
| The Research Progress of Neonatal Hypoxic-ischemic Encephalopathy |
| 投稿时间：2017-03-28 修订日期：2017-04-25 |
| DOI：10.13241/j.cnki.pmb.2018.03.042 |
| 中文关键词: 缺血缺氧性脑病（HIE） 神经发育障碍 亚低温 |
| 英文关键词: HIE Neurodevelopmental disorders Hypothermia |
| 基金项目:国家自然科学基金项目（81401231） |
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| 中文摘要: |
| 摘要：新生儿缺血缺氧性脑病(hypoxia-ischemia encephalopathy, HIE)是指围产期窒息导致脑的缺血缺氧性损害, 临床出现一系列中枢神经系统异常的表现，部分患儿可留有不同程度的神经系统后遗症，如脑瘫、癫痫、认知和运动功能发育障碍等，至今仍是导致新生儿死亡以及神经发育障碍的一大原因。HIE的发病机制复杂，是一个多环节、多因素的病理生理过程。单一治疗措施很难彻底治愈，需多种治疗措施联合使用，才能取得更好疗效。HIE 发病迅速，病情进展快，治疗过程中应积极把握治疗"时间窗"。临床上目前应用最广泛的治疗方法是亚低温结合其他对症治疗措施。新生儿HIE难以有效预防，及时正确评估新生儿出生时状态，尽早发现异常并进行治疗是改善HIE预后最有效的方法。本文就HIE的病因，诊断，治疗和预后等方面的进展进行介绍。 |
| 英文摘要: |
| ABSTRACT: Neonatal hypoxic-ischemic encephalopathy (HIE) is an important cause of acute neurologic injury at birth, mainly due to perinatal asphyxia. There are a series of abnormal manifestations of central nerve system, and part of infants with HIE would remain long-term devastating neurodevelopmental sequelae, like cerebral palsy, seizures, cognitive and motor dysfunction. Despite recent ad- vances in obstetric and neonatal care, HIE still associated with death and neurodevelopmental disorders of newborns worldwidely. The pathogenesis of HIE is complex, involving multi-link and multi-factor. Therapeutic hypothermia(TH) is now widely recommended as a standard of care for infants with HIE.The timing of TH is critical, mostly induced within 6 h of an acute asphyxia insult. It's hard to pre- vent HIE. Assessing the state of infants at birth correctly and treating the problems timely are significant. This review is a introduction of pathogenesis, diagnosis, treatment progress and prognosis of HIE. |
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