| 孙振蕊,丁 琳,闫 璐,刘晓弟,沈丹妮.翼状胬肉的发病机制及治疗的现状与进展[J].,2018,(3):577-580 |
| 翼状胬肉的发病机制及治疗的现状与进展 |
| Pterygium: Its Pathogenesis and Current Situation and Progress of Treatment |
| 投稿时间：2017-10-06 修订日期：2017-10-30 |
| DOI：10.13241/j.cnki.pmb.2018.03.040 |
| 中文关键词: 翼状胬肉 发病机制 治疗现状 神经生长因子 |
| 英文关键词: Pterygium Pathogenesis Treatment status Nerve growth factor |
| 基金项目:乌鲁木齐市科学技术计划项目（Y141310043） |
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| 中文摘要: |
| 摘要：翼状胬肉具有较高的发病率，作为眼表疾病之一，如不给予及时有效的治疗会对患者的外貌产生影响，同时造成视力受损。迄今为止，翼状胬肉的具体发病机制尚未完全明确，且治疗方式复杂多样。为了有效提高翼状胬肉的治疗效果，降低复发率，研究学者与临床医师开始针对翼状胬肉的发病机制开展了大量研究，同时对临床治疗方式也进行了诸多改进，且将新型的药物以及医疗器械应用于临床治疗中，为翼状胬肉的防治提供了新的思路。但是其确切的发病机制还有待进一步研究，本文在角膜缘干细胞缺乏、炎性细胞因子、病毒感染细胞凋亡、转化生长因子-?茁、神经生长因子（NGF）以及血管内皮细胞生长因子（VEGF）方面的研究进行了综述。 |
| 英文摘要: |
| ABSTRACT: Pterygium has a higher incidence, as one of the ocular surface diseases, if not given timely and effective treatment, it will have an impact on the appearance of patients, and it can cause visual impairment. So far, the specific pathogenesis of pterygium has not yet been fully defined, and the treatment is complex and diverse. In order to effectively improve the curative effect of pterygium and reduce its recurrence rate, researchers and clinicians began to carry out a large number of studies on the pathogenesis of pterygium, at the same time, the clinical treatment methods have also been improved. The new drugs and medical devices have been used in clinical treatment, which provides a new way of thinking for the prevention and treatment of pterygium. However, the exact pathogenesis remains to be further studied. In this paper, the research progress in limbal stem cell deficiency, inflammatory cytokines, virus infection, apoptosis, transforming growth factor beta, nerve growth factor (NGF) and vascular endothelial growth factor (VEGF) are reviewed. |
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