| 彭随风,时昭红,石 拓,万 莹,杨 健.黄芪当归汤联合莫沙比利治疗功能性便秘的疗效及对血清胃肠激素水平的影响[J].,2018,(2):321-325 |
| 黄芪当归汤联合莫沙比利治疗功能性便秘的疗效及对血清胃肠激素水平的影响 |
| Functional Constipation: Curative Effect of Astragalus and Angelica Decoction Combined with Mosapride and its Influence on Level of Serum Gastrointestinal Hormones |
| 投稿时间：2017-05-01 修订日期：2017-05-23 |
| DOI：10.13241/j.cnki.pmb.2018.02.028 |
| 中文关键词: 黄芪当归汤 莫沙比利 功能性便秘 疗效 胃肠激素 |
| 英文关键词: Astragalus and angelica decoction Mosapride Functional constipation Curative effect Gastrointestinal hormone |
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| 摘要 目的：研究黄芪当归汤联合莫沙比利治疗功能性便秘的临床疗效及对血清胃肠激素水平的影响。方法：选择2015年3月至2016年5月我院接受治疗的功能型便秘患者86例。按照随机数字表法分为观察组与对照组，各43例。对照组患者给予莫沙比利治疗，观察组同时加用黄芪当归汤治疗，对比两组临床疗效、不良反应；检测患者治疗前后血清胃动素（MTL）、P物质（SP）水平；采用SF-36生活质量量表对患者治疗后的生活质量进行评价。结果：观察组治疗总有效率为95.35%（41/43），显著高于对照组的81.40%（35/43），差异有统计学意义（P＜0.05）。两组腹痛、皮疹、稀便发生率对比，均无统计学意义（均P＞0.05）。治疗前两组血清胃肠激素水平对比无显著差异，治疗后两组MTL均降低，而SP均上升，且治疗后观察组MTL水平显著低于对照组， SP水平显著高于对照组（均P＜0.05）。治疗后观察组患者饮食、精神、睡眠以及心理四个维度的生活质量评分均显著高于对照组，差异均有统计学意义（均P＜0.05）。结论：黄芪当归汤联合莫沙比利治疗功能性便秘具有显著的临床疗效，能有效改善患者血清胃肠激素水平，提高患者生活质量，且安全可靠，值得推广应用。 |
| 英文摘要: |
| ABSTRACT Objective: To study the curative effect of astragalus and angelica decoction combined mosapride in the treatment of functional constipation and its influence on the level of serum gastrointestinal hormones. Methods: A total of 86 patients with functional constipation, who were treated in Wuhan No.1 Hospital from March 2015 to May 2016, were selected and randomly divided into observation group(n=43) and control group(n=43). The control group was treated with mosapride, while the observation group was treated with astragalus and angelica decoction. The clinical efficacy and adverse reactions of the two groups were compared. The levels of serum motilin (MTL) and substance P (SP) were detected before treatment and after treatment. The quality of life of patients after treatment were evaluated by SF-36 life quality scale. Results: The total effective rate[95.35%（41/43）] of observation group was significantly higher than that[81.40% (35/43)] of control group, the difference was statistically significant (P<0.05). There was no significant difference in the incidence of abdominal pain and rashes, loose stools between the two groups (all P>0.05). There was no significant difference in the serum level of gastrointestinal hormones between the two groups before treatment. After treatment, the levels of MTL of the two groups were all decreased, while the levels of SP increased, and the level of MTL in the observation group was significantly lower than that in the control group, the level of SP was significantly higher than that in the control group (all P<0.05). After treatment, the life quality scores of diet, spirit, sleep and psychological quality in the observation group were significantly higher than those in the control group, the differences were statistically significant (all P<0.05). Conclusion: Astragalus and angelica decoction combined with mosapride in the treatment of functional constipation can effectively improve the patients' serum gastrointestinal hormones level and improve their life quality, and it is safe and reliable, which is worthy of popularization and application. |
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