| 张 怡,张甘霖,孙 旭,于明薇,王笑民.硫酸乙酰肝素、肝素酶及其与肿瘤转移的关系[J].,2018,(1):190-194 |
| 硫酸乙酰肝素、肝素酶及其与肿瘤转移的关系 |
| Heparan Sulfate, Heparanase and Their Relationship with Tumor Metastasis |
| 投稿时间：2017-02-23 修订日期：2017-03-18 |
| DOI：10.13241/j.cnki.pmb.2018.01.041 |
| 中文关键词: 硫酸乙酰肝素 肝素酶 肿瘤转移 |
| 英文关键词: Heparan sulfate Heparanase Tumor metastasis |
| 基金项目:国家自然科学基金项目（81373815）；高等学校博士学科点专项科研基金项目（20131107110014）；北京市自然科学基金项目（7162084） |
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| 中文摘要: |
| 摘要：细胞外基质和基底膜的降解是癌细胞穿透组织屏障发生转移的重要步骤。硫酸乙酰肝素蛋白聚糖是细胞外基质和基底膜的组成成分，其多糖侧链可以被葡萄糖苷内切酶--肝素酶，特异性识别并切割，以破坏细胞外基质和基底膜的完整性，促进肿瘤转移。临床上肿瘤患者肝素酶高表达与肿瘤恶性程度和转移发生密切相关。深入了解硫酸乙酰肝素、肝素酶及它们与肿瘤转移相关的作用机制有助于我们寻找肿瘤治疗的新思路。本文将从硫酸乙酰肝素的合成调控、功能、肝素酶的转录和活性调节、肝素酶表达与肿瘤患者的临床特征，以及硫酸乙酰肝素、肝素酶与肿瘤转移的关系进行综述。 |
| 英文摘要: |
| ABSTRACT: Degradation of extracellular matrix and basement membrane is the significant procedure of cancer metastasis, as can- cer cell penetrates tissue barrier. Heparan sulfate proteoglycan is the major component of extracellular matrix and basement membrane, and its polysaccharide side chains can be specifically cleaved by heparanase, a kind of endo-?茁-D- glucuronidase; subsequently, the struc- tural integrity of extracellular matrix and basement membrane is impaired, which prompts cancer metastasis. The overexpression of hep- aranase in cancer patient is associated with grade malignancy of cancer and metastasis. It is helpful to understand the action mechanism of heparan sulfate and heparanase in cancer metastasis for investigating new methods of cancer treatment. This article will summarize synthesis regulation and function of heparan sulfate, transcription and activity regulation of heparanase, heparanase expression and clini- cal characteristics of tumor patients, the relationship among heparan sulfate, heparanase and cancer metastasis. |
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