| 付冬霞,张云娜,郭宁宁,赵乃蕊,许金秀,王光亚.2型糖尿病合并非酒精性脂肪肝患者的临床特征及与慢性并发症的关系研究[J].,2017,17(36):7155-7159 |
| 2型糖尿病合并非酒精性脂肪肝患者的临床特征及与慢性并发症的关系研究 |
| Clinical Features of Type 2 Diabetes Mellitus Patients Complicated with Nonalcoholic Fatty Liver Disease and its Relationship with Chronic Complications |
| 投稿时间：2017-05-16 修订日期：2017-06-12 |
| DOI：10.13241/j.cnki.pmb.2017.36.036 |
| 中文关键词: 2型糖尿病 非酒精性脂肪肝 临床特征 慢性并发症 |
| 英文关键词: Type 2 diabetes mellitus Nonalcoholic fatty liver Clinical features Chronic complications |
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| 中文摘要: |
| 摘要 目的：探讨2型糖尿病（T2DM）合并非酒精性脂肪肝（NAFLD）患者的临床特征，并分析其与糖尿病慢性并发症的关系。方法：选取2016年1月至2017年1月期间来我院就诊的T2DM患者245例作为研究对象，根据肝胆超声和生化检查结果，将单纯T2DM患者105例作为对照组，将T2DM合并NAFLD患者140例作为观察组，对比两组的一般情况和生化指标，并采用单因素和多因素Logistic 回归分析T2DM合并NAFLD与大血管慢性病的关系。结果：与对照组比较，观察组病程较短，HDL-C水平较低，BMI、SBP、TC、TG、LDL-C、ALT、AST、HbA1c、FINS、INS-120、HOMA-IR、FPG、2 hPG、空腹C肽、餐后2 h C肽水平较高（P<0.05）。观察组大血管发病率明显高于对照组（P<0.05）。Logistic回归分析结果显示，T2DM合并NAFLD患者合并大血管慢性病的影响因素依次是：BMI、HOMA-IR、SBP、LDL-C、HbA1c、TG。结论：合并NAFLD的T2DM患者糖尿病大血管慢性病发病率显著增加，合并NAFLD的影响因素依次为BMI、HOMA-IR、SBP、LDL-C、HbA1c、TG。 |
| 英文摘要: |
| ABSTRACT Objective: To investigate the clinical characteristics of type 2 diabetes mellitus (T2DM) patients complicated with nonalcoholic fatty liver disease (NAFLD) and to analyze its relationship with chronic diabetic complications. Methods: A total of 245 patients with T2DM, who were treated in Cangzhou Central Hospital of Hebei Province from January 2016 to January 2017, were chosen as subjects. According to the results of hepatobiliary ultrasound and biochemical examination, 105 patients with T2DM only were taken as control group, 140 patients with T2DM combined with NAFLD, as observation group. The general situation and biochemical indexes of the two groups were compared; univariate and multivariate Logistic regression analysis were used to analyze the relationship between T2DM complicated with NAFLD and macrovascular chronic diseases. Results: Compared with the control group, the observation group had a shorter course of disease, HDL-C level was lower, BMI, SBP, TC, TG, LDL-C, ALT, AST, HbA1c, FINS, INS-120, HOMA-IR, FPG, 2hPG, fasting C peptide and postprandial 2 h C peptide were higher (P<0.05). The incidence of macrovascular disease in the observation group was significantly higher than that in the control group (P<0.05). Logistic regression analysis showed that the risk factors of T2DM complicated with NAFLD patients with macrovascular chronic disease were as follows: BMI, HOMA-IR, SBP, LDL-C, HbA1c, TG. Conclusion: The incidence of diabetic macrovascular chronic disease significantly increased in T2DM patients with NAFLD, and the influencing factors of complicating with NAFLD are BMI, HOMA-IR, SBP, LDL-C, HbA1c, and TG. |
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